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▲ hk__2 4 hours ago

> Which is why I find it pretty funny that Ozempic is arguably the biggest weight-loss breakthrough in decades - and all it does is make you…eat less. Billions in R&D, and the answer was the platitude the whole time. Ha.

The problem was not that we didn’t know what to do ("eat less"), but to enable that solution.

▲projektfu 3 hours ago | parent | next [-]

I would push back and say that a lot of people didn't actually know that. They came up with elaborate reasons why eating less doesn't work, but keto works, or paleo works, or eliminating sugar works, or vegan works, or it's just physically impossible to lose weight.

▲NikolaNovak 3 hours ago | parent | next [-]

I am constantly arguing with all of my friends and family who believe primary way to loose weight is to exercise more.

Exercising is great, absolutely, but eating less is the actual primary method. While acknowledging complications of metabolism and psychology and weird states body goes through when it's hungry, primary part is to reduce calory intake vs expenditure.

So as snide and silly as it may be, in my neck of the woods, I would agree, lots of people don't believe eating less is the primary method of losing weight.

▲JohnMakin 3 hours ago | parent | next [-]

It’s just physics, really.

A bag of doritos is 200+ calories. The exercise involved to burn that off is running or walking multiple miles. It’s way easier in terms of physical expenditure to just not eat the doritos, or skip the sugary soda.

▲mnw21cam 2 hours ago | parent | next [-]

When I go hiking for a couple of weeks (with significant elevation gain each day), I eat like a pig. I mean, something like 5000 calories a day. I lose weight over that time. So it's possible to lose weight through exercise, however you really do have to spend a very significant chunk of each day doing it for it to work.

Not eating as much takes much less of your busy day.

▲JohnMakin 2 hours ago | parent [-]

If you are exercising on a caloric deficit, you are going to feel constantly tired and shitty. I find it way easier to just be on a caloric deficit.

▲nemomarx an hour ago | parent | next [-]

it's so much faster to do both at once though, and you retain more muscle mass during it and so on

so long as you can live like a monk and hit the gym every night for a few months it's pretty good. this is dependent on you being able to stand being hungry and cranky and going to bed exhausted for all that time though

▲skeeter2020 an hour ago | parent | prev [-]

this is not true; I do extended bikepacking trips nutrionally similar to the GP's experience and you feel amazing. Maybe your first time or the first day can be tough but the human body loves to move and consume. I think a good frame of mind is you're a high efficiency furnace pumping out the heat on a very cold day. but this machine actually heals & improves the more it's used!

▲Retric an hour ago | parent [-]

That’s only true over a relatively short period.

Stuff you can do for a week doesn’t automatically extend to maintaining that over the next 50 years.

▲skeeter2020 an hour ago | parent | prev | next [-]

I do agree that losing weight is easier at first with just eating less, but to play the advocate role: you need a gap of about 3500 calories to lose a pound, but there's a hard daily floor of zero calories. You need to eat less over a long period of time (ideally the rest of your life) and exercise (or medication more commonly) is what keeps you going.

▲watwut an hour ago | parent | prev | next [-]

If I eat less, I feel shitty, tired and passive. I move less naturally, because it sux. When I exercise, I feel good, eat as much as I feel like and am keeping/loosing weight.

▲chistev 2 hours ago | parent | prev | next [-]

"you can't outwork a bad diet"

▲bonesss 2 hours ago | parent | prev [-]

“You can’t outrun the fork.”

▲aeturnum 29 minutes ago | parent | prev | next [-]

I mean, these things are multimodal. For most people it's easier to cut enough calories to lose weight than it is to exercise enough to lose weight (though both are physically possible). But, of course, if you are losing weight you should be exercising! It's the best way to retain muscle mass, which is vital for health.

I am sure that when I've lost weight it's more the portion control than the exercise - but the exercise is a critical component. When you go from being sedentary to doing even casual exercise you feel better and get more energy - which you can then use to be more active. Without some kind of virtuous lifestyle-change cycle you are likely not going to shift your body mass, kind of no matter what ultimately puts you over the edge.

▲mrguyorama 2 hours ago | parent | prev [-]

The problem, as it is for a shitload of women, is that the delta between "Minimum amount of calories needed to not be somewhat malnourished" and "calories you eat now without losing weight" is sometimes zero. Short women working desk jobs are fucked

I was with a girl that barely ate, and couldn't get her weight down for about a decade because of that. Eventually she got really excited about a local dance studio and suddenly her weight dropped like a rock. She had to exercise more, but that was miserable until she found exercise that was effective and actually clicked, then it was trivial

Meanwhile it was trivial for me to eat less, because my budget should be around 1800 calories a day, and I was eating 3000. It's easy to cut out an entire bag of doritos. It is less easy to literally starve yourself.

People seem to forget as well that when you cut calories, your body will scream bloody murder until it re-adjusts. My body was convinced I was starving while I was 50 pounds overweight and eating 2000 calories because I had previously eaten more. Your body did not evolve in an environment where that was ever the wrong thing to feel! "Please eat more or we die" is one of the most powerful biological signals.

That these medications cut that signal is entirely why they work! If people just "couldn't stop eating" then not having hunger or appetite signals wouldn't have worked either.

▲nemomarx an hour ago | parent | next [-]

Getting down to 1200 or 1400 calories is pretty restrictive yeah. You can't do it without counting and meal prep the same way you can go from 3000 to 2000 by skipping snacks

As soon as the diet requires cutting out a daily meal or changing the contents of meals in really harsh ways (like no bread) it's going to get on your nerves and make you neurotic.

▲watwut an hour ago | parent | prev [-]

> People seem to forget as well that when you cut calories, your body will scream bloody murder until it re-adjusts

When the body does not scream that murder, it is called anorexia. And it is much worst for your health then obesity.

▲kube-system an hour ago | parent | prev | next [-]

"Eating less" as a strategy for losing weight is like "make a lot of money" is a strategy for becoming rich.

It certainly works, it is just an unhelpful strategy.

▲rrr_oh_man 40 minutes ago | parent [-]

Nah, the better analogy is "don't spend more than you make".

▲lkey 2 hours ago | parent | prev | next [-]

Keto changes the way you feel about eating if you enter ketosis for long enough.

Fasting does too, for that matter.

Paleo is just trendy keto with some woo on top.

The don't use the same mechanism as glp, nor do they have same success rate, but similar idea.

Eliminating sugar makes it harder to consume a 64oz soda at 800 calories in 3 minutes and still be hungry.

Anywho, most diets achieve some weight-loss.

But! keeping your mind and body from demanding you eat more to return to homeostasis is actually the 2nd hard part, and the part that most people fail at. And we'll see how much glp losses are sustainable (without shots) here pretty soon.

Regardless, this technology is good and we should subsidize everyone getting to a healthy weight. Searching for reasons they are actually morally inferior or stupid is counterproductive.

▲skeeter2020 an hour ago | parent | next [-]

isn't it widely accepted that supressed appetite (i.e. what makes glp work) is ONLY sustainable on the shots, and that you're on them for life?

▲nemomarx an hour ago | parent [-]

This is true for diets too. You have to keep doing whatever the new behavior is to keep it up.

So maybe the goal is use the drugs to shift your lifestyle to eating less, having less food in the house, and being more active and then wean off it

▲projektfu 2 hours ago | parent | prev | next [-]

True that. I think that many people who use GLPs to find a healthy weight will be on them, possibly intermittently, long term. It may be possible to retrain their eating habits, but I would not bet on it for most people.

▲howunfortunate an hour ago | parent | prev [-]

> we'll see how much glp losses are sustainable (without shots) here pretty soon.

Will we?

The idea is to be on them for life; I don't know that I've seen anyone recommend differently.

▲skeeter2020 an hour ago | parent | prev | next [-]

I agree sort of, but the argument here is do the simple thing, like "eat less". There; we're done - ha! My initial reaction (and also with the chose boring tech) is that's not the solution, that's where you start LOOKING for the solution! So boring is great, simple is fantastic - from a position of understanding. Too many people jump onto any "new thing" - diet, technology, whatever - because it's easy and right in front of them. Simple is often neither.

▲hn_throwaway_99 3 hours ago | parent | prev | next [-]

I would push back against your pushback and say nearly everyone knows that, it's just the brain is great at making excuses when things are physically difficult.

▲thomastjeffery 3 hours ago | parent | prev [-]

They did that because the other thing didn't work. It doesn't matter that the reason it didn't work is that they can't do it: the implication is identical.

Don't underestimate how impossible it can be to force your own body into a new behavior pattern.

▲jcalx 3 hours ago | parent | prev | next [-]

Classic case of "simple != easy". Things can be simple, yet hard, and that's an underrated measure of difficulty in my experience.

▲hansvm 3 hours ago | parent [-]

That's true, but the fact that it wasn't easy created a huge industry of fake information regarding alternative explanations of weight loss from CICO. It's nice to have some more obvious evidence to convince people that no, your body can't magically move and exercise for free when you eat less, among other strange claims I've heard from people struggling to lose weight. People stuck in that rut of not being able to eat less were prone to being deceived by countless weight loss products when the real solution (also hard mind you, but at least more viable) would have been to focus on which activities and diets actually allowed them personally to maintain a calorie deficit.

And as a bonus, now they also have one. A lot of people didn't even believe that was the solution though, and the belief change is important.

▲skinfaxi 4 hours ago | parent | prev | next [-]

The problem was always about enablement. We know the solution to smoking too, the problem is enablement.

▲lubujackson 3 hours ago | parent | next [-]

The interesting solution to smoking was social pressure. No smoking in restaurants, no smoking on planes, general intolerance to smokers, insane taxes on tobacco... suddenly, smokers for 30 years started quitting at a certain breaking point.

The real solution to weight loss (especially in the U.S.) is to change the social norms. When everyone is hitting the buffets and going to Cheesecake Factory and buying high calorie garbage at a discount, of course to population gets fat. France, for example, makes all of that much harder. Maybe Ozempic will help reduce the Walmart-wheelchair-fat population, but truly becoming fit as a country requires significantly more friction for everyone.

▲lkey 2 hours ago | parent | next [-]

Nicotine addiction has not been 'solved'.

Tobacco consumption still causes about one of every five deaths in the United States each year (439k). That number won't start going down (due to alternatives) until 2030, according to AJPM. Phillip Morris ($PM) is near an all time high, despite killing millions.

It killed both my grandfathers, it's likely killed someone you knew and loved, please get your facts straight.

And on your other point, fat people already get a lot of social 'friction', from people exactly like you who call them 'people of walmart' who eat 'garbage'.

A fat person who has exercised more and eaten less than you, and lost weight every day for a year will still be called a 'lazy fat-ass' by a person like you until they actually reach the promised land of 'normal'. (and before you ask to invalidate my opinion. No, I am not fat).

On France, Paris is a delightfully walkable city. US cities are car-or-else (excepting NYC). We're the ones who made our people sedentary.

You are on HN, most people here are hacking the attention economy to keep people seated and glued to screens.

Are you willing to vote to give up your car and a part of your future compensation to be surrounded by fitter people?

The social changes you have imagined are forms of shame/intolerance maximization (governments should not do this!), rather than designing our world around good food, human movement, and healthy habits (a thing governments can and should do!)

Regardless, GLPs are an absolute win, and once most people are a healthy weight I hope you will dial back on you reflexive disdain.

▲kortilla an hour ago | parent [-]

Nicotine addiction isn’t the problem though, you’ve just shifted the goal posts. A nicotine pill is not giving someone lung cancer.

▲nemomarx 3 hours ago | parent | prev | next [-]

The nice thing about ozempic is that it makes people less hungry and less able to eat large portions. Once 30% of the country is on it, expect buffets to go out of business and restaurants to need to shift to smaller portions in response. So it'll make it easier for everyone not on the drugs too.

▲rrr_oh_man 36 minutes ago | parent [-]

> Once 30% of the country is on it, expect buffets to go out of business and restaurants to need to shift to smaller portions in response

It's funny how a buffet in almost every other country really just exists for the self-serving simplicity/cost-savings and a broad-ish selection for customers, not to trigger overeating.

▲wcarron 2 hours ago | parent | prev [-]

Ironically, nicotine suppresses appetite. Maybe the solution was chain smoking all along.

▲zoeysmithe 2 hours ago | parent | prev [-]

This ignores how food today isn't much like food of the past. It has all manner of added sugars and things to make it more marketable, hence higher profits, but also causes over-eating. Snack culture is pretty much an attempt to make food as addictive as possible, and many of those methods are in 'regular' food too.

Not everyone knows this and many who do can't afford an expensive farm to table whole foods diet.

Now toss in car culture and the suburban model and a culture very strongly against any sort of socialized commons like public trans and the little exercise they otherwise would get isn't available anymore. I live in a walkable neighborhood and take public trans, I know my health would be much worse if I didn't get all those steps, fresh air, sense of community, etc in everyday.

Pretty much everything Americans do is wrong when it comes to food, diet, walkable communities, and transportation. What we need to fix this is not putting everyone on ozempic, but a frank look at how our society is organized and figuring out ways to move to a saner society.

▲yttrium 29 minutes ago | parent | prev | next [-]

Reducing the (frankly near-miraculous) host of effects that GLP-1 medications induce in the human body to "make you eat less" is grounds for instant mistrust. There is so, so, so much more that goes into them than just reducing appetite (whether it's helping your brain modulate dopamine signals, smoothing out glycemic control, reducing inflammation more generally, the list goes on). I think the pharmaceutical industry is as guilty of time and money wasting as anyone, but billions in R&D did actually yield quite a coup this time!

▲inglor_cz 2 hours ago | parent | prev | next [-]

After reading this sentence, I don't trust the author. Misleading as hell.

The success of GLP-1 is based on the fact that the patient can eat less without suffering. No food noise, reduced feelings of hunger, smaller stomach capacity.

Saying that the platitude works is like saying that "just stop doing fentanyl" is the recipe to solve the fentanyl crisis in the US.

▲stonedivot an hour ago | parent [-]

But the people claiming that they were some special case that just "couldn't lose weight" no matter how little they ate were bullshitting you. They couldn't handle the suffering, and as such the calorie intake was larger than the calories burned. They wanted you to believe eating less wasn't the solution. The drug proves that it WAS the solution, suffering aside.

▲howunfortunate an hour ago | parent | next [-]

"No matter how little they ate" was always ridiculous, obviously everyone knows that literally not eating anything would result in weight loss.

To me personally, the drug proved that people really ARE special cases.

Before Ozempic, I lost about 80 pounds "naturally", by suffering immensely, then kept it off for years, again by suffering immensely. Every day, hunger was at the forefront of my mind all day, every day. It was the #1 concern in my life.

I eventually gained back about 40 pounds, then went on Ozempic.

It has been an eye opener because I now realize what it's like to not suffer from hunger. I realized for the first time that this is how "normal" people feel, all the time! The only way I could get fat now is by eating junk - so in a weird way I started to understand the judgement about being fat.

Some people are just "calibrated" correctly, and that was absolutely mind blowing to me.

▲inglor_cz 8 minutes ago | parent | prev | next [-]

"suffering aside."

This is precisely the thing that cannot be put aside without making the solution much less useful / efficient / solution-esque.

▲IncreasePosts an hour ago | parent | prev [-]

What percent of obese people were saying that? Who exactly are you arguing against?

▲Thanemate 4 hours ago | parent | prev | next [-]

I'm far from being an expert on this specific subject but, I have the impression that Ozempic does a lot of things in one's body in order to reduce the appetite and result in eating less. Which is to say that, the author sounds like he's implying that the solution to this was trivial all along, by deliberately omitting the underlying mechanism that makes it work.

▲the__alchemist 3 hours ago | parent | prev | next [-]

I will poke at the last sentence a bit, as it's important to understanding the phrnomena you described. There was and is a lot of FUD about this. Many people knew it's true, including from first hand experience.

Discussion about it in news, conversations would get it mixed up into stories of genetics, free will, macronutrient balance, personal identities, culture etc. Call it nuance; complexity, or bullshit. People had/have a hard time accepting "eat less to not be fat".

This is one of the things you actually can change about your body, appearance and health outcomes! There are many things that are immutable - people would try to convince you the biggest mutable thing is also out of reach.

▲pixl97 an hour ago | parent [-]

>People had/have a hard time accepting "eat less to not be fat".

It's kind of like saying "Smoke less to avoid lung cancer". You can say eating is a fatal addiction. If you stop you die. The hard part is is balancing it so you keep on living and avoid the negative health outcomes.

Why is this hard? First the cause and effect are separated by a lot of time. If I eat a sweet fat sugary treat I get the good feeling RIGHT NOW. The negative health effects are way later.

Other reasons it's hard is our eating habits are mostly created in our childhood and very hard to break as an adult. If your parents fed you poorly you're at a significant health disadvantage.

The last one I'll list is crap food marketing. The most unhealthy crap seems to have the brightest packages to catch our eye. It has huge amounts of salt, fat, and sugar, things our evolutionary body craves because the number one thing it wants to avoid is starvation.

So yea, it is reachable, but it is not trivial at all.

▲hn_throwaway_99 2 hours ago | parent | prev | next [-]

The whole irony is that quote is making the exact mistake his post is about: "eat less" is great advice for people where eating less isn't that hard, but it's not helpful advice for people who struggle mightily with eating less and who live in an environment of calorie rich, nutrient poor foods. I've naturally always been skinny, I often find eating a chore. Eating less is incredibly easy for me, but eating right and exercising enough to maintain muscle is the hard part for me.

I mean, we've been telling people "eat less" for literally decades and Americans are fatter than ever. The only thing that finally brought down societal-wide obesity stats was GLP-1s.

▲bonesss 2 hours ago | parent [-]

“Eating less” is the bottom line, but the road there can be fraught.

Many people don’t understand what the high calorie drivers in their diet are, many wildly mis-estimate how much they’re eating, most people inflate the weight loss impacts of training and neglect the appetite rebounds, and the interplay between insulin and appetite and how to manage satiety signals is voodoo for even a lot of doctors. Availability of proper food and time to prepare it are hurdles on top of hurdles.

My estimation is that a lot of people are using way, way, more energy and willpower in their ‘diet’ cycles than necessary but tragically getting poor results because of miscalibration. Our society is geared around profitable food delivery, not healthy dietary wisdom.

▲Razengan 4 hours ago | parent | prev | next [-]

And we laugh at AI for being simple minded

The mind is always the biggest battle

▲mock-possum an hour ago | parent | prev | next [-]

It is literally crazy how many people, (particularly women, just an observation) have told me that they are some sort of special case, where eating less food will not make them lose weight. Earnestly told me to my face that “calories in, calories out” is simply not true for everybody. “Where do you think the matter that makes up your body comes from??” I ask incredulously, already knowing that this is just going to get me into trouble.

Obviously there are dozens of completely legitimate social and physiological complicating factors, but at the end of the day, you are what you eat; but there is a certain segment of the population who refuses to believe it. They hold sacred the food they consume and the weight they gain.

▲sublinear 30 minutes ago | parent [-]

This one has a super simple answer. They eat too many carbs.

When carbs spike their blood sugar, insulin swoops in to convert the excess glucose into fat. When they try to restrict calories, they focus on cutting the wrong macros. Calories from carbs are hard to avoid and easily miscounted/underestimated unless you're literally weighing the food and know every ingredient used.

You're not even wrong that women are more likely to have a sweet tooth and fall for crap diets like "low fat" or "plant based". It's decades of evil marketing at play here. The result is not only that they stay fat, but then lose muscle and the number on the scale doesn't budge.

You know what's a whole lot easier to eyeball and get full on? Meat and veg you cooked yourself. That's the easiest solution by miles, but people will continue serving themselves way too much pasta and bread (because it looks right on the plate), adding sauces that are smuggling even more carbs, eating ultraprocessed junk loaded with sugar you can't even taste or filler carbs to cut production cost, and saying their occasional piece of "fun size" candy or favorite drink "doesn't count".

▲sublinear 2 hours ago | parent | prev | next [-]

In the first place, the focus on weight loss is missing the point. Weight loss is just a side effect of metabolic change, and ideally you want to lose the fat instead of muscle.

Any means of positive metabolic change is fine, but some are better than others. Ozempic is definitely on the lower tiers of success because the body recomp and more meaningful habits never happen.

▲9rx 3 hours ago | parent | prev | next [-]

To be fair, we also knew how to enable it long before Ozempic arrived. We had hundreds of thousands of years of successfully "eating less" to look back upon for answers.

But drugs allow one to remove themselves from society, which is far more appealing.

▲nemomarx 3 hours ago | parent | next [-]

Basically every diet program for the last 4 years, every change to food or social habits at least in the US, failed to curb it. So in a pretty real sense we did not know how to eat less successfully, emphasis on successfully.

▲9rx 3 hours ago | parent [-]

Yes we do. We toss out the technology and go back to substance farming or hunter/gathering. You'll have no trouble "eating less". But that requires social coordination and humans much prefer to escape society through the use of drugs. Always have, always will.

▲nemomarx 3 hours ago | parent | next [-]

I think the revolt you'd get from trying to move everyone back to subsistence farming (and also getting conquered by some other group who didn't do this) also means we don't know how to do that successfully. You're ignoring that last word again.

▲9rx 3 hours ago | parent [-]

Protip: Read right up to the end of the comment before pressing reply. You missed a whole lot of context by rushing to respond midway through.

▲nemomarx 3 hours ago | parent [-]

What I'm saying is that "knowing how to do something" requires knowing how to actually implement that solution, how to get people to agree to do it. You might as well say "we know how to get to tau ceti".

▲Goronmon 2 hours ago | parent | prev | next [-]

Is it helpful to point out solutions for problems facing society that don't apply to "humans"?

▲wat10000 2 hours ago | parent | prev | next [-]

Yes, mass starvation is an extremely effective weight loss technique. However, some feel there are downsides to this approach.

▲watwut 2 hours ago | parent | prev [-]

There is an implicit requirement of "while not making survival chances significantly lower".

▲hansvm 3 hours ago | parent | prev | next [-]

Are you saying that Ozempic allows you to escape society or that all the fat people are actually just druggies? Like, either way it's wild, but I'm struggling to come up with a more charitable take.

▲ragall 3 hours ago | parent [-]

Both are true.

▲pixl97 an hour ago | parent | prev [-]

> We had hundreds of thousands of years of successfully "eating less"

Ah yes, our old friend starvation.

▲mrbenjihao 3 hours ago | parent | prev [-]

Plenty of options exist that enable the solutions around weight loss. The issue is that 99% of those are difficult to either start and/or maintain consistency with. Ozempic just happened to address both of those issues in one swoop because people as a whole are incredibly intolerant to any friction in their lives.

▲mszcz 2 hours ago | parent [-]

I'm sure your comment is made in good faith and I agree with it (in meaning), but this:

> because people as a whole are incredibly intolerant to any friction in their lives

...somehow makes me picture you saying it with a smug expression and instantly dislike the whole comment. Maybe it's the broad, catch-all "because people" generalisation, I don't know. But again, I agree with the comment... in meaning ;(

▲mrbenjihao an hour ago | parent [-]

The phrasing could have been chosen better but the meaning still stands. Amongst all of the valid and accessible options for weight loss, society will without a doubt choose the weight loss pill/shot bar none. All for the simple reason of minimizing friction above all else.