Reducing the (frankly near-miraculous) host of effects that GLP-1 medications induce in the human body to "make you eat less" is grounds for instant mistrust. There is so, so, so much more that goes into them than just reducing appetite (whether it's helping your brain modulate dopamine signals, smoothing out glycemic control, reducing inflammation more generally, the list goes on). I think the pharmaceutical industry is as guilty of time and money wasting as anyone, but billions in R&D did actually yield quite a coup this time!