| ▲ | Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma(twitter.com) |
| 152 points by heydenberk 2 hours ago | 45 comments |
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| ▲ | GenerWork an hour ago | parent | next [-] |
| This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma. |
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| ▲ | Insanity 35 minutes ago | parent | next [-] | | +1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either. | | |
| ▲ | jjice 33 minutes ago | parent [-] | | I didn't know about the UV index or what it meant until like three years ago. It blows my mind I went that long without understanding. It was actually wonderful to learn that I could just see if I needed sunblock based on a 0-10 scale. We never wore sunscreen as kids because we didn't burn. I probably have had three sunburns in my life. Learned once I became an adult that that wasn't sound logic... |
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| ▲ | Noaidi 10 minutes ago | parent | prev [-] | | [flagged] | | |
| ▲ | anonymars 7 minutes ago | parent [-] | | Article: "two forms of rare melanoma are not caused by exposure to the sun.." > Most skin cancers are not a big deal, and even Melanomas can vanish on their own PSA: don't take medical advice from internet comments |
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| ▲ | consumer451 an hour ago | parent | prev | next [-] |
| This appears to be a potentially huge win for health. The market has Moderna up 153% at time of writing, which is some sort of validation I suppose. Related stories: https://www.fiercebiotech.com/biotech/merck-and-modernas-per... https://www.reuters.com/legal/litigation/merck-moderna-say-m... https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ... |
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| ▲ | Jyaif 39 minutes ago | parent [-] | | oh nice. If it goes up another 100% I may not lose money on this stock anymore. | | |
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| ▲ | nearbyyak 29 minutes ago | parent | prev | next [-] |
| Huge, uplifting, news, hope the study will bear further fruit. Considering that 90% of all clinical trials fail, it's good to read about a truly promising one for once. |
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| ▲ | MartinMond an hour ago | parent | prev | next [-] |
| I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the... |
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| ▲ | epistasis 4 minutes ago | parent | next [-] | | I think the "expected value" was priced in, but regardless of the result, this trial would move the stock price towards that direction. Biotech is one of the very very very few areas of the stockmarket where specialist knowledge generates alpha. Trolling through random biotechs, learning about their tech, and investing in the most promising applications of that tech in the most impactful areas is something that happens somewhat on publicly traded markets. With tech, most of that happens pre-IPO. | |
| ▲ | henry2023 an hour ago | parent | prev | next [-] | | Even if you were to optimally price in all available information you still have uncertainty of what will actually happen. i.e. A 1 dollar coin flip has an expected value of 50c before it’s thrown and it will collapse either to zero or to one after the uncertainty is resolved. | |
| ▲ | mapipolo 27 minutes ago | parent | prev | next [-] | | Hard to price in the political factors now involved in Moderna's success or lack of success. | |
| ▲ | bluGill 31 minutes ago | parent | prev [-] | | I don't believe the efficient market hypothesis. However even if you do, new information has arrived and that will affect the price. |
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| ▲ | epistasis an hour ago | parent | prev | next [-] |
| Ever since I first heard of them a decade ago, it seemed that mRNA therapeutic vaccines were going to be the next wave of massive improvements in care. It's taken a bit longer than I had expected, and it's not that mRNA is the only way to make these sorts of vaccines, it's just so much better than the alternatives. I'm very very excited to see what comes next. |
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| ▲ | jambalaya8 an hour ago | parent | prev | next [-] |
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| ▲ | tnel77 an hour ago | parent [-] | | Why? | | |
| ▲ | jimbo808 an hour ago | parent | next [-] | | People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived. Yet Yale-led researchers later detected circulating S1 and full-length spike as late as 709 days after vaccination. They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. That is a massive gap between what the public was told and what later evidence found. If a technology makes your cells produce a biologically active protein, regulators should establish where it goes, how long it can persist, and what prolonged exposure does before mass deployment. https://news.yale.edu/2025/02/19/immune-markers-post-vaccina...
https://www.medrxiv.org/content/10.1101/2025.02.18.25322379v... | | |
| ▲ | Arkhaine_kupo 5 minutes ago | parent | next [-] | | > People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived which is still the case, even in the Yale study. > That is a massive gap between what the public was told and what later evidence found. there is an even larger gap between basic epidemiology and what the public understands. Hard science is difficult to communicate on a good day, on a global pandemic with quacks getting tons of airtime and multiple labs finding conflicting results (due to speed to publish and bad experimental parameters) I would say that was communicated by health experts was surprisingly valid and accurate. | |
| ▲ | estearum 20 minutes ago | parent | prev [-] | | > They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. Not true. This was correctly disclosed in the trial results as a super super super tail risk. Once they realized that the (minuscule) risk could be even further mitigated by simply spacing out the booster schedule, they adjusted that (Feb 2022). Nobody was "left in the dark" | | |
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| ▲ | jambalaya8 an hour ago | parent | prev [-] | | [flagged] | | |
| ▲ | consumer451 an hour ago | parent [-] | | > (and yes, I have a background in this) Care to share what that is exactly? | | |
| ▲ | jambalaya8 5 minutes ago | parent [-] | | absolutely! there is nothing i would rather do than further assist in deanonymizing what little privacy might be left! you first! |
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| ▲ | reenorap an hour ago | parent | prev [-] |
| I have 1000 shares of mRNA woohoo! For all the hate I have for the COVID vaccine, I still believe in the underlying technology and I put my money where my mouth was and bought around $20. I think this is just the first of many cancer treatments mRNA will bring and I’m very excited for the future of the technology. |
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| ▲ | Someone1234 an hour ago | parent | next [-] | | > For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise. | | |
| ▲ | zulux 22 minutes ago | parent | next [-] | | I thankfully figured out my young children didn't need COVID vaccines. A little grumpy that the medical profession pushed them on children when they really did know that children weren't at risk nearly as much by then. Sloppy thinking like this is how we get RFK, love him or loathe him. | | |
| ▲ | martythemaniak 9 minutes ago | parent | next [-] | | You got RFK because half the population thought they were unique snowflakes who could not abide by the same simple rules as everyone else. The price he'll extract is significant impacts on health, wealth and well-being. | |
| ▲ | cassidius 6 minutes ago | parent | prev [-] | | Except that your children are still vectors for getting others sick. Vaccines are there not just for you but your community. |
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| ▲ | declan_roberts 37 minutes ago | parent | prev [-] | | I can't speak for other people but I was upset to enter a medical era where bureaucrats were forcing medical decisions on me. I was forced to get it or lose my job despite 1) working remotely, 2) having already had Covid and 3) being healthy and not at risk of Covid death but being the largest risk for myocarditis. | | |
| ▲ | hdhdhsjsbdh a few seconds ago | parent | next [-] | | Americans are so silly. Resentful of being told to do anything for their own good or the good of others because of “individual liberty”, yet so willing to lick the boot of the police state and corrupt crony capitalists. | |
| ▲ | Arkhaine_kupo 3 minutes ago | parent | prev | next [-] | | > I was upset to enter a medical era Did we enter a new era or where you not paying attention or affecting you before? Reminds me of the old adage of: Q: "Why is no one speaking about this?" R: "Is no one talking about this, or are you just 20 and its the first time you are hearing about it?" | |
| ▲ | searine 4 minutes ago | parent | prev | next [-] | | Because, it is always all about you... | |
| ▲ | martythemaniak 12 minutes ago | parent | prev [-] | | Is that when you entered that era? Or did you enter it when you were a newborn in the hospital, or a kid entering school? |
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| ▲ | bhaak 44 minutes ago | parent | prev [-] | | What are the reasons for the hate of the COVID vaccine? | | |
| ▲ | tasty_freeze 21 minutes ago | parent | next [-] | | There is a legitimate discussion of what can be mandated you do to your body. However, that discussion was largely side-tracked by the massive amount of disinformation (eg, "Plandemic") that circulated online. There are people who to this day swear that COVID-19 was just like the flu and simultaneously claim that the vaccine spike proteins have killed around 20M people. Not just crackpots, but people with reach, like Brett Weinstein on Joe Rogan's podcast. | |
| ▲ | declan_roberts 41 minutes ago | parent | prev | next [-] | | Probably one of the most polarizing issues of the last 5 years. | | |
| ▲ | epistasis 7 minutes ago | parent | next [-] | | "Polarizing" is a word that kind of applies, especially if one is trying to be polite, but really it's one of the most politically disinformed issues in a long long time. A bunch of grifters pushed fear, uncertainty, and doubt for personal gain, at the expense of the health of the nation. I try not to blame people who got tricked, but at some point we need to treat people like adults who are responsible for their own actions, and hold them accountable for the harm they perpetuate by believing BS and acting on it. A democracy cannot function when its members are low-functioning, and when bad information dominates. Those who spread disinformation, relish the conspiracy and disinformation because it makes them feel special emotionally, and wallow in the mess of it, are hurting us all. | |
| ▲ | Insanity 38 minutes ago | parent | prev [-] | | I don't recall it being as polarizing outside of the US, where there was a larger group of anti-vaxxers to begin with. But that might be my "outside US" bubble. | | |
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| ▲ | alexlesuper 40 minutes ago | parent | prev [-] | | Probably disinformation. |
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