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adamking 2 hours ago

Creatine is one of the few supplements I actually notice a difference if I quit taking. Happy to see it’s benefits extend to beyond performance in the gym.

YZF 11 minutes ago | parent | next [-]

The only thing I notice is the impact to my weight. I think it makes me marginally stronger but not a huge effect. I take it because research seems to indicate it's a net positive with a small effect and it seems very safe...

ravenstine 2 hours ago | parent | prev | next [-]

Funny because I'm not sure I quite notice it immediately when I stop taking it, presumably since the body retains a certain amount of it. But I definitely notice a difference when taking it the first day after not having had it a little while, especially when taking 20+ grams a day. It gives me so much mental energy and alertness that I won't get a whole lot of sleep, but the next day I end up feeling just fine. If I remember correctly, there have been at least 2 studies that suggested high doses of creatine reduce the side effects of suboptimal sleep, and that definitely seems to be the case in my experience.

boredemployee 2 hours ago | parent [-]

Isn't 20+ grams a day a lot for the kidneys? genuine question

yesb an hour ago | parent | next [-]

Elevated creatinine levels (in absence of supplementation) is a sign of kidney issues. There are many studies showing no reverse link i.e. supplementing creatine damaging kidneys

https://link.springer.com/content/pdf/10.1186/s12882-025-045...

dev1ycan 3 minutes ago | parent [-]

Okay but logically kidney issues leading to high creatine does suggest that creatine is not all that good for the body, no? else why would the kidney keep it under control?

unshavedyak an hour ago | parent | prev [-]

Not the parent, but someone else commented on this: https://news.ycombinator.com/item?id=48347735

an hour ago | parent [-]
[deleted]
unshavedyak 2 hours ago | parent | prev | next [-]

What sort of differences beyond gym related?

j45 2 hours ago | parent [-]

After 10g or so, the excess starts going to the brain which helps quite a bit with brain energy.

cryptoegorophy an hour ago | parent [-]

What exactly does it do? What is brain energy?

the_sleaze_ 38 minutes ago | parent [-]

A good question, but we don't know what anti-depressants do or how they do it, same with anti-psychotics, mood stabilizers, psychedelics, etc. I think we can say we have good theories for creatine.

We do know that it does do something at certain doses.

Mistletoe 2 hours ago | parent | prev [-]

I feel like it makes me feel like crap and my brain weird every time I try it and searching my spreadsheet shows this effect many times when I forget and read something like the above article and try it again. Anyone else feel like this?

Silagi an hour ago | parent | next [-]

Are you increasing your water intake when you do? That sounds like dehydration. Creatine takes a large amount of water to appropriately process, and during the loading phase, your body is pushing substantially more water into your muscles. Anecdotally, if I don't drink something like an extra half gallon of water a day while loading at 15g/day, I show symptoms of dehydration. And I'm already drinking somewhere between a half gallon to a gallon a day.

Mistletoe an hour ago | parent [-]

I think I do but I guess I could try.

willy_k an hour ago | parent | prev | next [-]

Yes I can definitely “feel” it when I take it, especially so at 10g+. And it makes me overly reactive and somewhat irritable, and gives me a ton of energy that needs to be let out lest the former two get worse.

davidmurdoch 2 hours ago | parent | prev [-]

> searching my spreadsheet

What does this mean?

dgellow an hour ago | parent | next [-]

They likely keep a journal of their mental state in a spreadsheet? Generally a good idea

Mistletoe an hour ago | parent | prev [-]

I keep a spreadsheet about my health, blood work, any supplements I take, how they make me feel etc. The summary would be that I take zero supplements now haha. I have tried so so many.