| ▲ | Aurornis 7 hours ago |
| I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells. In other words, don’t expect to replicate these results with normal recreational use. |
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| ▲ | KennyBlanken 2 hours ago | parent | next [-] |
| I suppose this might be why Willie Nelson is still doing pretty good these days... |
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| ▲ | mrosett 6 hours ago | parent | prev | next [-] |
| Reminds me of this classic: https://xkcd.com/1217/ |
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| ▲ | farmdawgnation 5 hours ago | parent [-] | | There may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true. | | |
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| ▲ | jojobas 6 hours ago | parent | prev | next [-] |
| Can't have Alzheimer's if you don't have much of a brain left. |
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| ▲ | throwaway27448 5 hours ago | parent [-] | | Can you explain the joke? | | |
| ▲ | lithocarpus 5 hours ago | parent | next [-] | | If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/ | | |
| ▲ | Spivak 4 hours ago | parent [-] | | Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle. | | |
| ▲ | johnisgood 10 minutes ago | parent | next [-] | | What are your issues with opioid-based painkillers? | |
| ▲ | laserdancepony 4 hours ago | parent | prev [-] | | We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium. | | |
| ▲ | Muvasa 2 hours ago | parent | next [-] | | you got nsaids, metamizole, acetoaminophen, duolexitine. And you got a couple of more that work for neuropathic pain. The biggest problem with nsaids is that they cause bleeding and kidney failure, ulcers hence can cause stomach cancer. Here is a site you can use too see how most pharmaco therapy is lacking. https://pain-calculator.com/calculators/osteoarthritis-pain/ | |
| ▲ | hermanzegerman 2 hours ago | parent | prev [-] | | Metamizol is banned in the US, so they've robbed themselves of that |
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| ▲ | xeromal 5 hours ago | parent | prev | next [-] | | Sounds like this is more "Pouring bleach on germs kills the germs but it also kills everything else" | |
| ▲ | bitwank 5 hours ago | parent | prev [-] | | [flagged] |
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| ▲ | 7 hours ago | parent | prev [-] |
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