you got nsaids, metamizole, acetoaminophen, duolexitine. And you got a couple of more that work for neuropathic pain. The biggest problem with nsaids is that they cause bleeding and kidney failure, ulcers hence can cause stomach cancer.

Here is a site you can use too see how most pharmaco therapy is lacking.

https://pain-calculator.com/calculators/osteoarthritis-pain/