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verdverm 4 days ago

mRNA...

2021 - saved millions of lives

2023 - won a Nobel Prize

2025 - cancelled by an anti-vaxxer

latchkey 4 days ago | parent | next [-]

May have gotten some of this wrong and probably missing a bunch, but...

  1960's - discovered
  1970's - delivered into cells
  1987 - protein development
  1990's - more development
  2013 - potential vaccine for rabies
verdverm 4 days ago | parent [-]

Yea, there is a much longer history.

What's really crazy is that this is the same (?, 2.0) administration that championed the Project Warpspeed that led to this sequence of events. You'd think they'd be talking up how great they did and all the potential mRNA has to MAHA, yet here we are...

latchkey 4 days ago | parent [-]

Good point! He gave the reigns to a nutter and fired the folks that actually did the project. Bonkers!

Phil_Latio 4 days ago | parent | prev | next [-]

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OCASMv2 4 days ago | parent | prev [-]

> 2021 - saved millions of lives

Not really, the virus mutating into less aggressive strains did. Reducing counter-productive treatments (like ventilators) helped greatly too.

lamontcg 4 days ago | parent | next [-]

The virus didn't mutate into less aggressive strains, everyone got T-cells through vaccination or infection, which made subsequent infection less severe.

Which is borne out through the higher death rate in Republicans who didn't get vaccinated, compared to Democrats who did.

And we had situations like Hong Kong which got absolutely hammered by Omicron, even though that strain was supposedly "less severe", because of the low levels of prior infection and vaccination when Omicron hit there.

OCASMv2 4 days ago | parent [-]

> Which is borne out through the higher death rate in Republicans who didn't get vaccinated, compared to Democrats who did.

Or because republicans never took the threat seriously and didn't took effective preventive measures like reducing social contact, increasing their exposure risk.

> And we had situations like Hong Kong which got absolutely hammered by Omicron, even though that strain was supposedly "less severe", because of the low levels of prior infection and vaccination when Omicron hit there.

Hong Kong focused all its efforts in preventing the virus to even get there. Once it broke through they were unprepared to deal with it, hence the bad outcome.

lamontcg 4 days ago | parent [-]

> Or because republicans never took the threat seriously and didn't took effective preventive measures like reducing social contact, increasing their exposure risk.

Everyone got exposed eventually. Republicans who didn't vaccinate died at a higher rate when they got exposed.

> Hong Kong focused all its efforts in preventing the virus to even get there.

Yes, that's why it produced a good example of an immunologically naive population, late in the pandemic.

> Once it broke through they were unprepared to deal with it, hence the bad outcome.

Which was Omicron, and it turned out to be just as deadly. Which completely falsifies your argument that mutation led to less deadly strains.

We can see in Hong Kong that it was just as deadly.

In the United States it wasn't, and the difference is due to immunity from vaccination and natural infection.

OCASMv2 3 days ago | parent [-]

> Everyone got exposed eventually. Republicans who didn't vaccinate died at a higher rate when they got exposed.

Again, due to differences in risk behavior not limited to anti-covid measures.

> Which was Omicron, and it turned out to be just as deadly. Which completely falsifies your argument that mutation led to less deadly strains.

Not really since there's no mention of the treatment or lack thereof used there. You assume the outcome is due to lack of previous exposure when it can just be poor management.

But hey, at least is nice to see people who admit natural infection confers protection. That wasn't the case during the pandemic.

lamontcg 3 days ago | parent [-]

> But hey, at least is nice to see people who admit natural infection confers protection. That wasn't the case during the pandemic.

That is incorrect. Nobody with a passing familiarity of the human immune system would claim that natural infection didn't confer immunity. It just also carries a substantially higher risk of death and disability compared to vaccination.

verdverm 4 days ago | parent | prev | next [-]

The problem is that this is so ideological for some people, damn the science and facts, lies and positioning are all that matter in the post-truth world

Imagine believing that in a world of billions, that the vaccine didn't save at least 2M lives through reductions in symptoms and spread. The same is true for virus mutations

OCASMv2 4 days ago | parent [-]

It's perfectly reasonable to believe that when the vaccine in question is crap that doesn't prevent transmission, whatever limited positive effects it has last very little time and has severe side effects like heart inflammation.

chimprich 4 days ago | parent | prev | next [-]

> Not really, the virus mutating into less aggressive strains did.

This didn't happen. There was no selection pressure on the virus to mutate to a "less aggressive" form. To think there was is to fundamentally misunderstand the science here.

The incubation period was plenty long enough for the virus to spread before incapacitating the host. All the selection pressure was for the virus to become more virulent - and that is precisely what happened. We saw multiple strains appear which were harder to deal with.

> Reducing counter-productive treatments (like ventilators) helped greatly too.

This had a negligible impact. Patients were only put on ventilation when they were already very sick and at a high chance of death. Worldwide only a tiny proportion of deaths came about in this way. Even rich countries only had ventilators in the tens of thousands. Compare that to the billions who received vaccinations.

OCASMv2 4 days ago | parent [-]

> The incubation period was plenty long enough for the virus to spread before incapacitating the host. All the selection pressure was for the virus to become more virulent - and that is precisely what happened. We saw multiple strains appear which were harder to deal with.

Is Omicron equally as deadly as Delta? No.

> This had a negligible impact. Patients were only put on ventilation when they were already very sick and at a high chance of death. Worldwide only a tiny proportion of deaths came about in this way. Even rich countries only had ventilators in the tens of thousands. Compare that to the billions who received vaccinations.

That's just one example. Not using effective antivirals is another one. With time, treatments improved and so did the outcomes, regardless of vaccination status.

chimprich 4 days ago | parent [-]

> Is Omicron equally as deadly as Delta? No.

It depends how you look at it. Omicron had a lower CFR, but higher transmissibility, so arguably worse.

There is no inherent selection pressure on viruses to mutate towards being less aggressive. Omicron had a transmission advantage that coincided with being a bit less lethal, but often being more transmissible correlates with being more lethal (e.g. delta variant).

We could have easily had a more lethal omicron variant emerge if it wasn't for vaccination effectively halting the pandemic.

Far more people were saved by vaccination than any luck on random mutation in the virus.

> With time, treatments improved

They did. Like the use of dextramethasone. Still a small improvement compared to the dramatic success of the vaccines.

> and so did the outcomes, regardless of vaccination status.

No. Vaccinated individuals were better off in pretty much every measurable statistic. By any reasonable measurement vaccination saved millions of lives.

OCASMv2 3 days ago | parent [-]

> We could have easily had a more lethal omicron variant emerge if it wasn't for vaccination effectively halting the pandemic.

Vaccination didn't even prevent transmission.

chimprich 3 days ago | parent [-]

What do you mean "prevent"? If you mean vaccines didn't completely prevent transmission, then yes. If you mean vaccines didn't prevent a proportion of transmission, then no. The vaccines did significantly reduce transmission in general.

Of course the main benefit of the vaccines was a dramatic reduction in severe disease, hospital admissions and deaths.

OCASMv2 3 days ago | parent [-]

They didn't affect transmission at all. Symptom reduction is also debatable since it can also be explained by immunity from previous exposure, less damaging variants and better treatments as time went on.

chimprich 3 days ago | parent [-]

There's plenty of evidence that vaccines reduced transmission, especially in the earlier variants.

The idea that vaccines didn't reduce severe illness is laughable. Multiple robust tudies across many nations and institutions have been carried out, showing that several different vaccines were highly effective.

insane_dreamer 4 days ago | parent | prev | next [-]

It was a combination of these factors that saved lives. mRNA vaccines played an important part.

Everyone can calm down now.

worik 4 days ago | parent | prev | next [-]

> Not really,

Yes, really

4 days ago | parent | next [-]
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OCASMv2 4 days ago | parent | prev [-]

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yahoozoo 4 days ago | parent | prev [-]

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