One of the challenges that are always going to be present when trying to skip podcast ads is that the vast majority (especially on larger shows) of ads are inserted dynamically even those that are read by the host. That means that not everybody gets them (geo targeted) and they may not be served to every listener at all times. Makes it a more challenging problem than the baked in sections of YT vids that Sponsorblock targets.

Exactly. The SponsorBlock system would need to be updated to support marking ad block stop and start points by audio signature (much more complicated than simple timestamps) or transcription (compute intensive).

Uh, that could be a problem, I was thinking on sponsors made by the podcaster itself, but some plattforms do insert extra adds (I saw them at the beggining or end) and makes sense that they are country-specific and not the same every time.