Uh, that could be a problem, I was thinking on sponsors made by the podcaster itself, but some plattforms do insert extra adds (I saw them at the beggining or end) and makes sense that they are country-specific and not the same every time.

Yeah, I would recommend this be VERY low on your priorities list because of all of the challenges involved.

There is a reason none of the major podcast apps have even attempted to do anything with ad blocking.