For those who may have tried other variants... is there a big difference between Ozempic/Wegovy/Mounjaro? My doctor prescribed WeGovy but my insurance does not cover it - my spouses does. However Mounjaro is covered by both insurances. Is it worth (effectiveness) switching to Mounjaro? I heard it is a 'double agonist' - what exactly does that mean?

I am also reading up on things called triple agonist but its not readily available in Canada. Web sites with a lot of discussion about peptides and titrating which seems a little difficult.

I've lost 28 lbs on Mounjaro in about 3-4 months. One injection per week, self-administered, completely painless. No more 6-8pm food cravings. That's on top of the money I save vs. eating out all the time (spending maybe $500-600 less per month than I used to, vs. $800 every 6 months for the medicine itself, without insurance). YMMV if you cook at home a lot, but I consider it one of the best lifestyle decisions I've made in recent memory.

Mounjaro is the more effective option of the 3 anyway so if that’s your goal and it’s covered, go with it. Double agonist means it targets two hormone pathways. I was on mounjaro for 6-8 months and no regrets. I was offered the 3 alternatives, and was explained the efficacy of mounjaro so went with that one. No reported downsides other than sulphur burps but I think that’s universal.

It works quite well. I have a ton of friends that have lost a ton on it. But the main benefit is the health side. My blood sugar with not just the the weight loss is back to normal.

Folks really only discontinue because of cost … which is because our health system is a disaster

Wegovy has a pill, super convenient if you don’t want to prick yourself with an auto injector every week, but requires a 30 minute fast every morning and might be less effective. Also, the pills travel better since they don’t require refrigeration. I pay out of pocket with an HsA around $330/month on Amazon.

I'll add that Zepbound is the same as Mounjaro, I believe (both add tirzepatide to the basic Ozempic/Wegovy drug).

I started wegovy 3 weeks ago (1.5mg oral dose) and so far have felt absolutely nothing, good or bad.

I'm assuming this is normal and something will happen when I up the dose.

Ozempic and wegovy are a much more primitive drug and gave me worse side effects. Mounjaro is significantly better and proven to be more effective. Ozempic is cheaper though.

I had a lot more success and less side effects on Zepbound vs Wegovy. I pay out of pocket for Zepbound through Lily Direct and even with a coupon it's $500 a month. Without the coupon it would be $2k a month! It's worth it for me, though even though it hurts my wallet.

The triple agonists like Retatrutide should be available in ~6 months assuming all goes well with their trials. Unless you are Trump who got special permission to get it before everyone else! https://www.statnews.com/2026/06/23/eli-lilly-unusual-weight...

[dead]