I think this is a geopolitical question beyond any cabinet or chair. In general, I think it would surprise people, but a Democratic cabinet would have to do many of the same geopolitical choices as Trump has done.

If you read Chokepoints by Fishman, it's for example clear that US had to do something with Iran soon, because all of the economical sanctional options were squeezed to the max, there was no offramp for that country.