| ▲ | yewenjie 2 hours ago |
| TBH, I am waiting for Mathocalypse-level progress in biology and medicine, but I guess that's not happening as fast, because it's the real world, human lives, etc., mostly etc. |
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| ▲ | ungovernableCat an hour ago | parent | next [-] |
| Math is completely abstract and the base rules and mechanics of it are some of the most clear cut and formalised because that’s the entire point of the subject. Biology is the complete opposite of that. |
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| ▲ | bijowo1676 22 minutes ago | parent [-] | | we do have high precision microscopes that can see molecules, so it is possible to build closed system with feedback loop that feeds back into AI at very small scales | | |
| ▲ | hungryhobbit 15 minutes ago | parent | next [-] | | I don't follow how "we can see tiny stuff" = "it is possible to build closed system"? Seeing tiny stuff doesn't magically give you enough info for Claude to reason with the system predictably (the way it can with source code). | |
| ▲ | lifeisloving 14 minutes ago | parent | prev [-] | | No its not, this is complete dunning kruger, please provide an example. |
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| ▲ | dennysora-main 2 hours ago | parent | prev | next [-] |
| Indeed, actually, one of the limitations preventing AI from making more contributions is humans. Human emotions, laws, morality, responsibility, and so on are all part of these limitations. I've always thought openai could actually create an agent that can control various physical robotic arms and things like that, and then continuously iterate on solutions that can participate in the real physical environment. This could accelerate automatic iteration for many things that require human operations, such as complicated experiments, assembly adjustments, and testing. Otherwise, AI is always trapped in virtual systems and still needs human intervention. But even though AI is already very powerful now, there is still a limit to how much humans can handle or assign tasks. Many times, AI has already finished processing something, but I don't even have time to assign the next deeper level of tasks. People hope AI can improve productivity, but at the same time they're afraid of AI actually getting involved in reality, while the valuation of the entire AI industry is so high. This kind of wanting to move forward but not moving forward makes humans especially uncomfortable. |
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| ▲ | xhevahir 2 hours ago | parent | prev | next [-] |
| I expect that AI use in the more axiomatic kinds of research will be well in advance of sciences that have a heavy, messy empirical foundation, like biology. |
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| ▲ | jareklupinski an hour ago | parent | prev | next [-] |
| first math; now its first integral w.r.t. time: physics, then second integral: chemistry, then third: biology finally, us |
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| ▲ | redanddead 2 hours ago | parent | prev | next [-] |
| That plus organs on a chip could be scalable and generate interesting data |
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| ▲ | sashank_1509 44 minutes ago | parent | prev | next [-] |
| I might be wrong, but I expect robotics to come before Biology. At least robotics is much easier to verify, most humans can look at a robot and let you know if it is working correctly or not. |
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| ▲ | DANmode 26 minutes ago | parent [-] | | Interesting topic, considering how many humans are unable look at themselves and know if they're working correctly or not! |
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| ▲ | shiandow an hour ago | parent | prev | next [-] |
| Oh I'd hope we can do better. Cures with only theoretical evidence and an inscrutable explanation for why they work sounds terrible. |
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| ▲ | slashdave 2 hours ago | parent | prev | next [-] |
| Keep waiting |
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| ▲ | enraged_camel 2 hours ago | parent | prev [-] |
| Specifically, it's because the verification loops are much longer in applied sciences. In biology you need to wait for wet lab experiments, clinical trials, regulatory steps, etc. before you can call something "solved". Since sequential steps are slow, I think we're going to see massive increases in parallelization. I'm not sure how the regulatory frameworks will keep up honestly. |
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| ▲ | slashdave 2 hours ago | parent | next [-] | | > we're going to see massive increases in parallelization Why? This is not an AI problem, it's an industry one. And if it was simple, it would already exist. | | |
| ▲ | xp84 2 hours ago | parent | next [-] | | Well, it matters more for AI because there are some limitations of human research that don't apply to AI. Not all of course, just mainly the fact that there's a finite number of great researchers. Other things are limitations that could theoretically be overcome -- for instance, it's "only" money stopping you from having more lab space as long as you have a suitable robot to run a lab. | |
| ▲ | menaerus 2 hours ago | parent | prev [-] | | > And if it was simple, it would already exist. Not necessarily. Many things are simply gatekept behind the door. |
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| ▲ | Bluestein 2 hours ago | parent | prev [-] | | > wet lab experiments, clinical trials, regulatory steps I wonder what the unlock would be, if any, of having simulations substitute any (or all, in time) of these steps. Akin to the method used to train FSD cars, or robots.- | | |
| ▲ | jurgenburgen 2 hours ago | parent | next [-] | | By the time we can simulate a human body to the degree that clinical trials aren’t necessary I think we have solved disease a long time ago. | | | |
| ▲ | vessenes an hour ago | parent | prev | next [-] | | You may recall Google published AlphaFold in the last few years -- its main goal is precisely this. Combining up that tech with these pipelines is likely to speed things up. It looks like things are already speeding up a lot based on the press release, though. This seems likely to be an area where we'll see some compounding returns over the next couple years. | | | |
| ▲ | xp84 2 hours ago | parent | prev | next [-] | | In my untrained opinion, I don't think that will be as much of a cheat as it might seem. Or more accurately, creating a simulation accurate enough to where it would work for this purpose would be where all the breakthroughs would have to be made. Building a perfect simulation requires an understanding of the system being simulated, that I don't think we fully have of molecular biology -- if we did, I suspect we'd already have many of the answers we are seeking when we do this kind of research. But I'm no biologist so if someone else is, feel free to correct me. | |
| ▲ | Bluestein an hour ago | parent | prev [-] | | All valid points on being able to simulate well enough meaning we would have nearly solved everything to begin with.- I wonder if, at some point, AI's will perform to such degree they are able to construct "black box" simulations as needed, that nobody understands BUT that are sufficient to empirically experiment on ... ... much in the same way LLM's function now: In an aggregate sense, they are bloack boxes.- |
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