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▲ ortusdux 2 hours ago

Are there risks to creatine?

▲mkotlikov an hour ago | parent | next [-]

As it was mentioned elsewhere it might make existing cancers worse, and decrease survivability. Cancer seems to love it.

https://pubmed.ncbi.nlm.nih.gov/25601461/ https://doi.org/10.1016/j.cmet.2021.03.009

More accessible video: https://www.youtube.com/watch?v=tcMgHncZVIw

▲BunsanSpace 2 hours ago | parent | prev | next [-]

Generally no, it's expensively studied and has had daily consumption to be safe for upto 5 years at least (studies haven't generally gone longer).

That being said some people do have adverse effects to supplementation, e.g. excessive water retention, bloating, stomach discomfort, &c.

So try it, if you have a bad reaction stop.

▲ZYbCRq22HbJ2y7 2 hours ago | parent | prev | next [-]

Maybe

https://www.frontiersin.org/journals/nutrition/articles/10.3...

▲luke5441 2 hours ago | parent | prev | next [-]

I get severe cramping from it (reproducible). All I can find are papers about this being a myth and some reddit threads about other people having this.

▲kenhwang 2 hours ago | parent | next [-]

I get it too if I don't drink a lot more water. So did many people on my sports team.

Creatine binds to water (making less water available to your muscles) and allows your muscles to work harder (which makes them need more water). So if you're not drinking a lot more water when you're taking creatine, you will get cramps from either dehydration and/or muscle overuse.

But once you're past the loading phase for creatine and getting sufficient hydration, it's supposed to lessen cramps because the water bound to creatine also becomes available for use again as the creatine is used by the body.

▲luke5441 an hour ago | parent | next [-]

Yeah, of course I tried to drink more water. I also tried to ramp up the dose slower.

But the cramps are really debilitating, as in random back muscle locks up debilitating, so I thought it best to just give up on this.

▲kenhwang an hour ago | parent [-]

I don't think dosing affects much, as long as you have excess creatine, the extra water requirements are determined by your muscle mass.

▲kelseyfrog an hour ago | parent | prev [-]

How much water can 3g of creatine bind to? Is it like orbeez?

▲kenhwang an hour ago | parent [-]

My understanding is it's a bit of a bind and release process that moves the water from outside of the muscle cell to inside of it until the cell is saturated or the creatine is consumed.

So the amount of creatine changes the rate as which water is loaded into the cell, but the total amount of water needed is calculated based on your muscle mass. The figures I've seen is 2L extra water (spread evenly, not all at once) for a normally recommended 5g daily creatine intake during loading (which typically takes a month at 5g/day dosage).

▲er4hn 2 hours ago | parent | prev | next [-]

I get this unless I drink a lot of water. About 48 fl oz seems to be the right amount for 10g creatine. Sometimes this needs to be combined with a light snack, like a handful of nuts.

▲andy_ppp 2 hours ago | parent | prev [-]

Did you try different sources I do not trust some of the stuff out there and often wonder if these supplements aren’t just generic white powder…

▲luke5441 an hour ago | parent [-]

That would be an argument against trying a different source

▲HedonicEscal8r 2 hours ago | parent | prev | next [-]

Essentially none. Creatine supplementation is a good idea for most people, especially vegans/vegetarians.

▲flossly 2 hours ago | parent [-]

Why especially those?

▲dgacmu 2 hours ago | parent | next [-]

Your body can synthesize creatine, so it's not essential, but meat is a source of exogenous creatine and eating it results in higher stored creatine levels, which is slightly good for muscle power endurance in the ~5-15 second effort range. Supplementing produces slightly higher relative improvements in creatine levels in vegetarians and vegans than it does in people who eat meat.

▲eknkc 2 hours ago | parent | prev | next [-]

Nobody gets fired for supplementing vegans.

▲hobo123 2 hours ago | parent | prev | next [-]

Because they lack all kinds of substances that meateaters get plenty of.

▲SmasherEpilepti an hour ago | parent [-]

I'm a vegan, and I'm surprised this is downvoted, because it's true. There are plenty of things that you need to be careful to not become deficient in on a vegan diet: protein (in appropriate amino acid balances), creatine, b12, the good Omega 3s (from algae preferably; flax is missing DHA entirely), calcium, iron, to name a few.

You're fine if you take daily algae oil, multivitamin, iron supplement, calcium, and creatine (without going overboard on any of it) and making sure to get lots of protein from balanced sources (eating a ton of soy is actually not a bad idea, because it's a balanced protein), but I wouldn't recommend somebody who doesn't want to have to worry about their nutrition to go vegan. Enough omnivores are already deficient in vitamins and minerals, and veganism only makes it harder.

▲iamdev 2 hours ago | parent | prev | next [-]

Because meat is the best source of creatine from diet.

▲hagbard_c 2 hours ago | parent | prev | next [-]

Well, if vegetarians and those of the Vegan religion don't get enough creatine it is most likely related to them not partaking of an important source of the substance: meat.

▲unethical_ban 2 hours ago | parent | prev [-]

Not vouching for creatine, but in general, humans get some vital nutrients from animal consumption. Vegans have to take some B-vitamins for best health due to what they don't get from meat. I assume creatine is the same.

▲asdff 2 hours ago | parent | prev | next [-]

It can make you hold more water weight so you should drink more water in response.

▲shawnwall an hour ago | parent [-]

i personally have problems with tinnitus and hearing loss, and creatine use tends to trigger it due to water retention so i stay off the stuff.

▲asdff an hour ago | parent [-]

Interesting, I wonder how that is related? Do you believe you are getting hearing loss because you are retaining more water, or because you are dehydrated from retaining more water elsewhere in the body with the same intake rate? Does this go away if you were taking creatine and drinking more water? Or does it come up if you simply drink more water?

▲ddoolin 2 hours ago | parent | prev | next [-]

Potentially lots poopies.

▲dilyevsky 2 hours ago | parent | prev | next [-]

Worse beach looks

▲nkozyra 2 hours ago | parent [-]

Creatine causes intramuscular water increases, not subcutaneous. Doesn't actually have a negative impact here.

▲colechristensen 2 hours ago | parent | prev | next [-]

Excessively large doses make your stomach and perhaps your kidneys unhappy and supplements being lightly regulated there may be purity issues where the risk is what else is in it.

But it's pretty safe at recommended doses.

▲pow_ext 2 hours ago | parent | prev [-]

None