>Do we have the numbers yet on the effects of vaping all day every day on cardiovascular health and lung cancer?

Not that I know of, and I grant that this is an unknown, and we could end up learning about extremely bad 20-/30-/40-year effects in the future. That said, there are very clear, very significant, and very well studied harms of cigarette smoking. Research is being done on vaping, and so far all harms identified are significantly lower than smoking.

>Also nicotine itself is not without harm.

Sure, and thanks for the paper. I'm not well versed in bio enough to tell the significance of everything in there, but, correct me if I'm wrong, for the most part this is showing there exist harms, but they're not particularly well quantified yet, especially in terms of human subjects? For this to really matter, you'd need to quantify the surplus of nicotine you get from vaping vs. smoking, and then compare the relative harms of those two doses. Could be that 5x the dose causes 5x the harm, or could be that the smoking dose passes some threshold, and 5x the dose from vaping is just marginal additional harm on top of that. And then still compare that to the other differences between smoking and vaping in terms of harm.

Keep in mind 5x the dose is relative to being a pack a day smoker. We're talking 20x if it means smoking 4-5x a day.

Then there is the negative effects of I dunno how many multiples of volume of vape in your throat and lungs, which I assume is non-zero even though I personally believe its 100x better than burning tobacco.

Then there is the question of what that much nicotine does to you mentally, which is equally, if not more important. To put it in perspective, I usually wake up feeling pretty good, with some hopes and dreams of what Ill be doing that day, and Ill take a puff and immediately want to go back to bed for another hour. I cant sit in meetings for more than 5 mins or have conversations with people if it means I cant be vaping. Its like basing your whole life based on whether you get your fix of nicotine or not. Work from office? I don't think so buddy...every ten minutes Id have to go to the bathroom/outside. I seriously wonder where my life would have been if I never picked up this habit.

We'll see in another 10-20 years I suppose.