Keep in mind 5x the dose is relative to being a pack a day smoker. We're talking 20x if it means smoking 4-5x a day.

Then there is the negative effects of I dunno how many multiples of volume of vape in your throat and lungs, which I assume is non-zero even though I personally believe its 100x better than burning tobacco.

Then there is the question of what that much nicotine does to you mentally, which is equally, if not more important. To put it in perspective, I usually wake up feeling pretty good, with some hopes and dreams of what Ill be doing that day, and Ill take a puff and immediately want to go back to bed for another hour. I cant sit in meetings for more than 5 mins or have conversations with people if it means I cant be vaping. Its like basing your whole life based on whether you get your fix of nicotine or not. Work from office? I don't think so buddy...every ten minutes Id have to go to the bathroom/outside. I seriously wonder where my life would have been if I never picked up this habit.

We'll see in another 10-20 years I suppose.