We should try GLP-1s. It patches the brain's reward center.

GLP-1 drugs may fight addiction across every major substance - https://news.ycombinator.com/item?id=47280797 - March 2026

GLP-1 medications get at the heart of addiction: study - https://medicine.washu.edu/news/glp-1-medications-get-at-the... - March 4th, 2026

https://news.ycombinator.com/item?id=45907422 (citations)

There is a fentanyl vaccine approaching human trials, but I don't believe its mechanism works close enough to the reward center. Maybe gene therapy is a long term fix as it relates to the reward center dysfunction, to be determined.

HN Search: fentanyl vaccine - https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...

Resetting the Brain’s Reward Pathway: Gene Therapy’s Breakthrough in Alcohol Addiction - https://scitechdaily.com/resetting-the-brains-reward-pathway... - August 20th, 2023

I have recently found the following article interesting:

https://en.wikipedia.org/wiki/FOSB

Specifically the part where a variant of this protein seems directly implicated in the specific self upregulation that leads to changes in the brains reward pathways that seem to directly cause the sort of "Drug seeking" and other addiction seeking behaviors that are so harmful in addiction.

I especially love the part where we tried inhibiting this protein expression with simple chemicals administered orally in rats and it significantly improved their addictions, and we did that in 2015, and we have not touched it since

Gosh, wouldn't it just be the best if we had spent $4 trillion on bioscience instead of GPUs? I feel like we understand circuits pretty well by comparison.