I have recently found the following article interesting:

https://en.wikipedia.org/wiki/FOSB

Specifically the part where a variant of this protein seems directly implicated in the specific self upregulation that leads to changes in the brains reward pathways that seem to directly cause the sort of "Drug seeking" and other addiction seeking behaviors that are so harmful in addiction.

I especially love the part where we tried inhibiting this protein expression with simple chemicals administered orally in rats and it significantly improved their addictions, and we did that in 2015, and we have not touched it since

Gosh, wouldn't it just be the best if we had spent $4 trillion on bioscience instead of GPUs? I feel like we understand circuits pretty well by comparison.