| ▲ | Modified3019 an hour ago | ||||||||||||||||
FYI, before reaching for PDE5 inhibitors, please be aware that these seem to be ototoxic in some way. Common side effects are tinnitus and to a lesser extent hearing loss. When taking these, you should track if there are changes to your hearing and cease immediately if you notice something. The damage seems cumulative and based on dose, and may resolve quickly, over months, or not at all. You should also look into any other medicines you take to see if they are ototoxic. | |||||||||||||||||
| ▲ | Noaidi 20 minutes ago | parent | next [-] | ||||||||||||||||
Fascinating! I have non-hearing damage induced Tinnitus and Bipolar Disorder and have been interesting in my PDE genetics for sometime as a link to my issues. It seems I have a natural inhibition of many PDE genes (PDE4B specifically, but I have some less studied changes in my PDE5A genetics which suggests an inhibition there as well). Sildenafil has been know to make BP people relapse in one case... https://academic.oup.com/ijnp/article/7/4/525/707950?login=f... And also investigated with some mood issues... https://link.springer.com/article/10.1007/s00213-023-06361-3 Zinc and Magnesium are cofactors for all the PDE genes and those have helped me, specifically the zinc. I have a feeling that low GTP is causing issues in ED since Cyclic GMP is made from GTP. | |||||||||||||||||
| ▲ | raspasov an hour ago | parent | prev [-] | ||||||||||||||||
Study link and/or source? | |||||||||||||||||
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