| ▲ | AFF87 8 hours ago |
| We are very early in the semaglutide world, exciting times ahead! |
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| ▲ | ndr 8 hours ago | parent | next [-] |
| For sure we still need to find out many related outcomes. Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss. https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi... |
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| ▲ | mapontosevenths 7 hours ago | parent | next [-] | | To save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes. Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's. I didn't check to see if other studies prove that. | | |
| ▲ | thrtythreeforty 7 hours ago | parent | next [-] | | It is well known that forcing a sudden drop in chronically high average blood glucose (like, from 200+ to a normal ish range) with insulin can cause vision loss. I wonder if it's the same mechanism? | | |
| ▲ | adam_arthur 7 hours ago | parent [-] | | It tends to happen when: 1) You must have a crowded optical disc as a precursor (low cup to disc ratio). Genetic and can be tested 2) You have stiff veins/arteries due to poor metabolic/cardio health 3) when blood pressure drops too much, blood flow can get cut off to the optical nerve temporarily due to reliance on high blood pressure due to 2 4) Due to loss of blood flow, optic nerve swells and closes blood flow into the eye due to 1 |
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| ▲ | adam_arthur 7 hours ago | parent | prev [-] | | It's also true that having a crowded optical disc is pretty much a required precursor condition to suffering NAION. Which you can get checked for via a $50 optical scan. No crowded disc, very little risk. (Cup to Disc ratio of 0.2ish or less starts to present risk) |
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| ▲ | tptacek 7 hours ago | parent | prev [-] | | In addition to being closely associated with the conditions semaglutide treats, NAION is quite rare. |
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| ▲ | AaronAPU 6 hours ago | parent | prev [-] |
| If it reduces inflammation and causes weight loss, I find it impossible to believe you can just stop and not get rebound on both. Which to me just sounds like every other addictive drug. Paradise while you’re high, and eventually you pay for it. |
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