For sure we still need to find out many related outcomes.

Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss.

https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

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mapontosevenths 7 hours ago | parent | next [-]

To save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes.

Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's.

I didn't check to see if other studies prove that.

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thrtythreeforty 7 hours ago | parent | next [-]

It is well known that forcing a sudden drop in chronically high average blood glucose (like, from 200+ to a normal ish range) with insulin can cause vision loss. I wonder if it's the same mechanism?

	▲	adam_arthur 7 hours ago \| parent [-]
		It tends to happen when: 1) You must have a crowded optical disc as a precursor (low cup to disc ratio). Genetic and can be tested 2) You have stiff veins/arteries due to poor metabolic/cardio health 3) when blood pressure drops too much, blood flow can get cut off to the optical nerve temporarily due to reliance on high blood pressure due to 2 4) Due to loss of blood flow, optic nerve swells and closes blood flow into the eye due to 1

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adam_arthur 7 hours ago | parent | prev [-]

It's also true that having a crowded optical disc is pretty much a required precursor condition to suffering NAION.

Which you can get checked for via a $50 optical scan.

No crowded disc, very little risk.

(Cup to Disc ratio of 0.2ish or less starts to present risk)

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tptacek 7 hours ago | parent | prev [-]

In addition to being closely associated with the conditions semaglutide treats, NAION is quite rare.