I think the real question with Ozempic is.....why are so many people's bodies not producing enough natural GLP-1 in the first place?

Ozempic is for sure a miracle for some who really need it but for many I think they would be better off by solving that problem at the source (likely gut bacteria based and consuming a better mix of prebiotic fibers). Increase your natural levels of GLP-1

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teiferer 2 hours ago | parent | next [-]

> I think the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place?

That's pretty easy: The last centuries (or decades, mostly) have provided an asymmetry in nutrition systems. Modern food engineering has optimized most of what people eat to have them crave more instead of being mainly filling. There is little to counter that, and GLP-1 is a way to do that. Another way is will power. Yet another is fixing what and how you eat (and how you exercise, but that'a a different topic).

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Melatonic an hour ago | parent [-]

Exactly. And that last one is the most important for long term results.

Plus it's not like you couldn't combine a GLP-1 drug with great diet and exercise

	▲	JumpCrisscross an hour ago \| parent \| next [-]
		> that last one is the most important for long term results Empirically untrue. GLP-1s outperform diet and exercise alone. > it's not like you couldn't combine a GLP-1 drug with great diet and exercise This is how it's recommended to be taken. I personally know folks who were able to start regularly exercising and eating healthily because of the head start GLP-1s gave them. (They're mostly off them now, and they're all materially lighter and healthier than they were before.)
	▲	kube-system 38 minutes ago \| parent \| prev [-]
		Diet and exercise guidance is the standard of care for prescribing GLP1s. But prescribing diet and exercise alone has long had mixed results, because it does nothing to address appetite, and it is even quite common for exercise to increase it.

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JumpCrisscross an hour ago | parent | prev | next [-]

> the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place?

Why can’t we synthesize vitamin C?

The root-cause solution to vitamin C deficiency is supplementation (through food or otherwise). If our bodies couldn’t figure something like this out, something the rest of the animal kingdom (apart from guinea pigs) did, it strikes me as conceivable is badly optimized in other cases, too.

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IncreasePosts an hour ago | parent [-]

Our bodies did figure it out(our common ancestor with the wet nosed primates could synthesize vitamin C).

But our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances.

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JumpCrisscross an hour ago | parent [-]

> our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances

But none of the other animals in our biomes similarly optimized? Including none of the other apes?

The less Panglossian interpretation is a gene got fucked up, it didn't wipe us out, and the fuck-up got conserved because it doesn't kill us before reproduction, it just makes us sicker from time to time.

	▲	an hour ago \| parent \| next [-]
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	▲	fragmede 32 minutes ago \| parent \| prev [-]
		Fascinatingly, we could biohack our way into having the human liver produce vitamin c, like we have the science to do that. It's just an insane amount of risk compared to just eating an orange once in a while.

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FeteCommuniste an hour ago | parent | prev | next [-]

Our "natural" impulse is to eat everything tasty within reach until we're full. That's not so healthy when the tasty stuff regularly includes foods like liter soft drinks, ice cream sandwiches, French fries, and so on. Our bodies didn't evolve with calorie-bombs constantly just a drive-thru trip away.

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thinkingtoilet 2 hours ago | parent | prev | next [-]

Millions of years of evolution and selection ending up at humans needing one food supply and lifestyle while modern life is basically the opposite. Endless calories. Sugar and meat everywhere. Our bodies are did not evolve for modern life. That's why.

	▲	cpursley 26 minutes ago \| parent [-]
		Meat? Errrr, did you mean to write refined white carbs? Those obsidian spear points were not for shucking corn…

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IncreasePosts an hour ago | parent | prev [-]

Because on an evolutionary time scale, we never had a consistent surplus of calories over a long period of time.

Imagine Grog and gang kill a mammoth but Grog only eats 500 calories before feeling so full he's going to throw up.