> I think the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place?

That's pretty easy: The last centuries (or decades, mostly) have provided an asymmetry in nutrition systems. Modern food engineering has optimized most of what people eat to have them crave more instead of being mainly filling. There is little to counter that, and GLP-1 is a way to do that. Another way is will power. Yet another is fixing what and how you eat (and how you exercise, but that'a a different topic).

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Melatonic an hour ago | parent [-]

Exactly. And that last one is the most important for long term results.

Plus it's not like you couldn't combine a GLP-1 drug with great diet and exercise

	▲	kube-system 37 minutes ago \| parent \| next [-]
		Diet and exercise guidance is the standard of care for prescribing GLP1s. But prescribing diet and exercise alone has long had mixed results, because it does nothing to address appetite, and it is even quite common for exercise to increase it.
	▲	JumpCrisscross an hour ago \| parent \| prev [-]
		> that last one is the most important for long term results Empirically untrue. GLP-1s outperform diet and exercise alone. > it's not like you couldn't combine a GLP-1 drug with great diet and exercise This is how it's recommended to be taken. I personally know folks who were able to start regularly exercising and eating healthily because of the head start GLP-1s gave them. (They're mostly off them now, and they're all materially lighter and healthier than they were before.)