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rayiner a day ago

GLP-1s aren’t “forever drugs.” They’re eliminated so fast from your system you need to keep taking them to keep the effect. That’s the opposite of a forever drug. If you go off them, you just return to the way you were.

SAI_Peregrinus a day ago | parent | next [-]

I think they mean they're drugs you have to keep taking forever (for the rest of your life) to keep the effects.

rayiner a day ago | parent [-]

Interesting. That usage is the opposite of “forever chemicals” though. Isn’t it a good thing GLP-1s don’t permanently change your body?

SAI_Peregrinus a day ago | parent [-]

It certainly can be a good thing! But it can also be considered a bad thing that you have to keep taking them, and have to keep paying for them forever. A one-time fix (a cure) can be more desirable than a lifelong treatment regimen.

tancop a day ago | parent [-]

how do you permanently cure obesity? you can try rewiring metabolism with crispr or some epigenetic changes but thats insanely risky, it would be very likely to mess up the immune system and give people cancer or nerve disorders.

maybe i could see something based on modified gut bacteria that produce GLP-1 drugs inside your body. that would run into problems with dose regulation but at least you can flush them out with antibiotics if you get a bad response.

cassianoleal a day ago | parent | prev [-]

Which means if you want to maintain their effect, you need to keep taking them forever. So maybe GP used the wrong term but I suspect they meant exactly this.

In any case, we just don't know what kind of long-term effects these drugs have. No one knows what happens if you come out of them 30 years after you started.

dd8601fn a day ago | parent [-]

You’re right, I did say that wrong, I suppose.