how do you permanently cure obesity? you can try rewiring metabolism with crispr or some epigenetic changes but thats insanely risky, it would be very likely to mess up the immune system and give people cancer or nerve disorders.

maybe i could see something based on modified gut bacteria that produce GLP-1 drugs inside your body. that would run into problems with dose regulation but at least you can flush them out with antibiotics if you get a bad response.