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tester756 a day ago

Why take drugs when you can take home-delivery diet?

This is genuine question, I've started using them and they're one of the best things I've ever paid for.

You get good food, at calculated sizes/calories/etc etc, you don't have to do shopping, cooking, cleaning, etc.

It is insanely convenient and you can manage your weight easily without even any exercises (but they're still recommended tho)

minimaltom a day ago | parent | next [-]

Usually, chronically-overweight ppl have tried regulating weight with all kinds of diets, lifecycle interventions, regular exercise, etc, and a lot of the time the thing that actually worked was the GLP-1. I think this speaks a lot to the variance in metabolism, hunger, cravings etc across the population.

asdff a day ago | parent [-]

The rub is that if they did a good job with those things, they would have worked. Most people cannot accurately account for calories and poorly estimate how hard they are actually working out.

minimaltom a day ago | parent [-]

I think this is a commonly-held misconception. Even when individuals accurately account for calories and workout intensity (using hard data, not feels), theres a large variance across individuals, broadly attributable to 'metabolics'.

asdff a day ago | parent [-]

While that is true there is variance it doesn't vary to the point of overcoming the basic thermodynamics at play. Facts are, you eat fewer calories, you lose weight. You burn more calories than previously without eating to make up the difference, you lose weight. There is no obese person that can starve themselves and not lose weight. It just doesn't work like that. The energy has to come from somewhere.

What often happens when people say "it doesn't work for me" is that they think they are working hard in the gym but aren't actually, or they think they are eating healthy without realizing all the little snacks or drinks they consume are putting some thumbs on the scale.

minimaltom a day ago | parent [-]

Sure the thermodynamic reduction of `weight-loss := energy-in < energy-burned` is true, but youre erroneously extending that reduction to assert basically ~variance in outcomes is explained by effort and measurement error~.

Most pointedly, theres a number of studies that measured outcomes from over/under-feeding identical twins [1] or varying exercise in identical twins [2] and found significantly wider variance WITHIN twin pairs than across the whole study. Phrased differently, calorie intake + exercise doesn't predict the outcome of weight even when controlling for hereditary factors, and looking at the geometric mean masks this.

TLDR the same amount of exercise + number of calories in one person doesnt predict the outcome in another. Hence why at-home delivery services doesnt eliminate the need for GLP-1 drugs.

[1]: n=12 twin pairs, Bouchard et al., NEJM 1990. [2]: "Mirror image experiment", Bouchard et al., Obesity Research 1994.

stephbook a day ago | parent | prev | next [-]

Why suffer hunger for the rest of your life when you can inject a drug weekly and it takes only 2 minutes?

https://www.nytimes.com/2023/06/21/well/eat/ozempic-food-noi...

codedokode a day ago | parent [-]

Because many drugs have side-effects, and they are different for different people. So if a drug helps one person, it might harm another.

Jaygles a day ago | parent | prev [-]

I've been overweight many times in my life, and I've been able to use diet and exercise to get my weight back to a healthy level.

Each occasion took a large amount of willpower and the healthy habits didn't stick around forever.

I started taking tirzepatide weekly and the most striking effect was a marked decrease in cravings. Where previously it took all my willpower to ignore cravings, it has now become difficult to overeat. I would have to force myself.

Now I wonder if its like this for those who have never had issues with their weight. Are there people who insist it's easy but have never experienced cravings?