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Could psilocybin be the key to treating anorexia?(scientificamerican.com)
25 points by tzury 2 hours ago | 22 comments
ulrikrasmussen 17 minutes ago | parent | next [-]

I lost a family member to anorexia, and the only thing I really regret is that I didn't suggest that we try psychedelic therapy now that everything else had failed and things looked pretty grim. I mostly blame myself for not pushing the idea. But I am also angry at the war on drugs which has caused all use of psychoactive drugs to be associated with such taboo.

inigyou an hour ago | parent | prev | next [-]

Psychedelics open your brain up to rewiring in some way, and can be used under direction to treat a lot of things. But of course, people who didn't like the Vietnam War used them recreationally, which is why the US government made them globally illegal.

joinjune an hour ago | parent | next [-]

Drug use changes the way you vote. The people who were running the country during the Vietnam war recognized this and, along with the people who owned industry/media, didn't want that kind of change to go mainstream.

tokai an hour ago | parent [-]

That was not why they started the war on drugs, and we have that on record.

MSFT_Edging 16 minutes ago | parent | next [-]

Yeah, Disenfranchise the hippies and the blacks by targeting those communities with heavy policing. Sorta like today where there's similar drug use levels between white and black populations, but one side is more heavily policed than the other.

guerrilla 16 minutes ago | parent | prev [-]

Always beleive the record...

an0malous an hour ago | parent | prev [-]

Psychedelics desolve the conceptual prison your mind is in, the government made them illegal because they build those prisons.

Charitably, you could argue a functional society involves some amount of indoctrination into a set of shared beliefs and a large percentage of people losing that indoctrination would destroy society. Could the US function if everyone was a pacifist, anti-capitalist, hippie? I think that was and still is the primary concern.

bushwart 17 minutes ago | parent | next [-]

Psychedelics can dissolve more than the mind's conceptual prisons, perhaps much more of the mind than one would like. How did the hippie-era stereotype of the burned out acid head disappear so quickly from popular culture?

mikert89 13 minutes ago | parent | prev | next [-]

anyone i have met that did Psychedelics more than a few times, permanently changed their brain chemistry in a way that was obvious. sure they dissolve some kind of prison, but many people never make it back from that dissolution and end up somewhere worse

inigyou an hour ago | parent | prev [-]

Interestingly, we know the CIA tried to use psychedelics to make people become the opposite of hippies, and they failed. This was part of MKULTRA. They were banned shortly after this failure.

mikert89 15 minutes ago | parent | prev | next [-]

Psychedelics arent that far from turning your brain off and then turning it back on again

but anyone i have met that did Psychedelics more than a few times, permanently changed their brain chemistry in a way that was obvious. clearly they are doing some kind of unraveling that doesnt fully bounce back

jhoechtl an hour ago | parent | prev | next [-]

We hear a lot of psilocybine lately, it cures altsheimer, people in coma awake miraculously. As long as we do not understand the workings, it reminds me of the days when radium or other nuclear substances were the cure for everything.

cachius 3 minutes ago | parent | next [-]

We hear a lot about LLMs lately, they solve reasoning, mimic empathy, and awaken consciousness miraculously. As long as we do not understand the workings of the mind and brain, it reminds me of the days when machine learning or Bitcoin were the cure for everything.

Cthulhu_ 21 minutes ago | parent | prev | next [-]

We don't fully understand the workings because it is (was?) classified as a drug, making research into it a lot more complicated. Thankfully there are charities and organizations that lobbied to make it more researchable.

inigyou an hour ago | parent | prev [-]

It's a drug that makes your neurons more susceptible to forming new connections. Of course it's going to be useful for a lot of brain treatment. In addition, it's highly illegal which means these things didn't get found out a lot sooner.

exhumet 15 minutes ago | parent [-]

upside is that in most states you can just go buy the spores and they just so happen to conveniently have spawn bags right nearby. BUT DONT EVER COMBINE THE TWO AND WAIT A FEW MONTHS

cainxinth an hour ago | parent | prev | next [-]

https://archive.ph/r7Rbt

llm_nerd an hour ago | parent | prev [-]

This feels like a case where Betteridge's law of headlines applies, or at least should be presumed. [Recreational Drug] solves [malady] is such a hopeful go to and has recurred countless times.

I've partaken of 'shrooms a number of times: Fun times. I've even grown them (protip - not worth the trouble. It's amazing how something that grows in literal shit is suddenly the most fragile process imaginable when you try your PFTek method, and contamination will always be ruining your process). But people keep trying to make psilocybin a magic solution, and the studies have been extremely weak if not contradictory, and these stories always lean on worthless anecdotes.

mosburger an hour ago | parent | next [-]

Here's yet another anecdote of near-zero real value to add to the pile: I treated my severe treatment-resistant depression with ketamine infusions. It's obviously not the same as psilocybin, but I believe the current thinking is that psychoelics and dissociatives both have some positive effect on neuroplasticity, and that sorta checks out in my case. I'd say you need to combine it with some good cognitive behavioral therapy - it seemed to make CBT a lot more effective for me where it failed in the past because my brain was more open to rewiring. I haven't been re-treated in a few years now, but I still feel a lot better.

But you're also totally right - my story is just an anecdote, and these sort of headlines that used to have cannabis as a miracle cure for all types of things seem to have been replaced with headlines about psilocybin (or occasionally, ketamine) curing everything instead. I totally get the skepticism, but I'm a believer that we might be onto something w/r/t depression or other things that are treatable via CBT at least - the article mentioned "combined with talk therapy" ... not sure what therapy method was used alongside the psilocybin.

MSFT_Edging 10 minutes ago | parent [-]

People tend to view these things as "pop the drug, and you're cured" but if you really want to make the most of the neuroplasticity, you need to make a conscious plan ahead of time so that you can guide the trip and focus on the problems you're genuinely facing.

The drug won't magically give you the answer but you may reach some more profound general breakthroughs regarding your own behavior, patterns you fall into unconsciously, etc.

Similar to how addiction and associated behaviors are really only resolved when the person addicted decides to make the change, you can use these to influence into a similar state.

jgalt212 an hour ago | parent | prev [-]

SciAm really should prefer a headline such as:

Psilocybin opens up new pathways to treating anorexia

phoronixrly an hour ago | parent [-]

Not even that... One quoted study says it 'provides preliminary support for the feasibility, safety and potential efficacy' of the drug. The other study is funded by a company selling psychedelics as potential medicines...