Here's yet another anecdote of near-zero real value to add to the pile: I treated my severe treatment-resistant depression with ketamine infusions. It's obviously not the same as psilocybin, but I believe the current thinking is that psychoelics and dissociatives both have some positive effect on neuroplasticity, and that sorta checks out in my case. I'd say you need to combine it with some good cognitive behavioral therapy - it seemed to make CBT a lot more effective for me where it failed in the past because my brain was more open to rewiring. I haven't been re-treated in a few years now, but I still feel a lot better.

But you're also totally right - my story is just an anecdote, and these sort of headlines that used to have cannabis as a miracle cure for all types of things seem to have been replaced with headlines about psilocybin (or occasionally, ketamine) curing everything instead. I totally get the skepticism, but I'm a believer that we might be onto something w/r/t depression or other things that are treatable via CBT at least - the article mentioned "combined with talk therapy" ... not sure what therapy method was used alongside the psilocybin.

People tend to view these things as "pop the drug, and you're cured" but if you really want to make the most of the neuroplasticity, you need to make a conscious plan ahead of time so that you can guide the trip and focus on the problems you're genuinely facing.

The drug won't magically give you the answer but you may reach some more profound general breakthroughs regarding your own behavior, patterns you fall into unconsciously, etc.

Similar to how addiction and associated behaviors are really only resolved when the person addicted decides to make the change, you can use these to influence into a similar state.