| |
| ▲ | rbehrends 17 hours ago | parent | next [-] | | Heritability has a very specific meaning in quantitative genetics [1], which in many ways is not what your intuition would suggest [2]. It is this usage that the article talks about that. That said, there are plenty of critiques of this definition of heritability, and not just because it is different from what a layperson would expect it to mean. For example, the way it is used also usually has a big problem in that the standard formula assumes that Cov(G, E) = 0 (or at least is negligible), whereas in practice that is not actually true [3, 4]. This definition of heritability is also mathematically flawed in that it assumes (without evidence) that P = G + E, or at least can be reasonably approximated this way. Given that human development is the result of a feedback loop involving genetic and environmental factors, one would expect a model closer to something like a Markov chain. Proposed justifications of a simple additive model as an approximation (e.g. via the central limit theorem for highly polygenic traits) have to my knowledge never been tested. More recent genome-wide association studies [5] have actually shown a considerable gap between heritability estimates from genotype data and heritability estimates from twin studies, known as the "missing heritability problem". [1] https://en.wikipedia.org/wiki/Heritability [2] https://en.wikipedia.org/wiki/Genetic_variance [3] https://en.wikipedia.org/wiki/Gene%E2%80%93environment_inter... [4] https://en.wikipedia.org/wiki/Gene%E2%80%93environment_corre... [5] https://en.wikipedia.org/wiki/Genome-wide_association_study | | |
| ▲ | codethief an hour ago | parent | next [-] | | OP has another post on the definition of heritability, which I really liked: https://dynomight.net/heritable/ . I'm a layman, though, so since you seem knowledgeable, I would love to hear your thoughts on that article! For instance, OP's definition H = Var[G] / Var[P] seems to bypass the issues you mentioned: > For example, the way it is used also usually has a big problem in that the standard formula assumes that Cov(G, E) = 0 (or at least is negligible), whereas in practice that is not actually true [3, 4]. > This definition of heritability is also mathematically flawed in that it assumes (without evidence) that P = G + E, or at least can be reasonably approximated this way. | |
| ▲ | IshKebab 16 hours ago | parent | prev [-] | | > Heritability has a very specific meaning in quantitative genetics [1] Literally the first paragraph of that page is > Heritability is a statistic used in the fields of breeding and genetics that estimates the degree of variation in a phenotypic trait in a population that is due to genetic variation between individuals in that population. The concept of heritability can be expressed in the form of the following question: "What is the proportion of the variation in a given trait within a population that is not explained by the environment or random chance?" That matches what I assumed it meant, and it seems like OP and the post are arguing that that is some kind of surprising interpretation. > OK, but check this out: Say I redefine “hair color” to mean “hair color except ignoring epigenetic and embryonic stuff and pretending that no one ever goes gray or dyes their hair et cetera”. Now, hair color is 100% heritable. Amazing, right? Uhm, no. That is exactly what I (and I think most people) would expect the answer to be. | | |
| ▲ | rbehrends 15 hours ago | parent [-] | | > That matches what I assumed it meant, and it seems like OP and the post are arguing that that is some kind of surprising interpretation. The unintuitive part is that in quantitative genetics, heritability is defined in terms of variance in traits at the population level, not as the passing of traits from parents to offspring (that would be heredity [1]). Of course, I may have misinterpreted what you said in your OP when you cited the wiktionary definition of "[g]enetically transmissible from parent to offspring", and if so, I apologize, but at the time it seemed to me that you were talking about heredity. > Uhm, no. That is exactly what I (and I think most people) would expect the answer to be. What the article is talking about is that if you fix Var(E) = 0, then Var(P) = Var(G) in the standard heritability model, i.e. all phenotypic variance is explained entirely by genotypic variance (because in that model, Var(P) = Var(G) + Var(E)). Fun fact (even if only tangentially unrelated): In Western countries, wearing glasses is a highly heritable trait, because wearing glasses is a strong proxy variable for refractive error [2], such as nearsightedness, which is highly heritable. It is often brought up as another example of how the quantitative genetics definition does not match conventional use of the word. [1] https://en.wikipedia.org/wiki/Heredity [2] https://en.wikipedia.org/wiki/Refractive_error |
|
| |
| ▲ | tptacek 17 hours ago | parent | prev | next [-] | | The heritability statistic that occurs in the literature is the ratio of genetic variance to phenotypic variance. Two corrollaries: * When discussing heritability results from the literature, we are discussing that statistic, not your intuitive understanding of what the word should mean. * In the scientific literature, your conception of heritability doesn't operate. In the scientific sense, the number of hands you have has low heritability, despite being genetically determined. I think you're going to find "let's check Wiktionary" is not the decisive move in these kinds of discussions that it is elsewhere. | | |
| ▲ | AgentME 16 hours ago | parent [-] | | Another great example of the unintuitiveness of heritability is the fact that earrings are highly heritable. Earrings are highly correlated to a specific genetics (being female), so they're very "heritable", even though that correlation is an arbitrary cultural fashion. |
| |
| ▲ | IronyMan100 18 hours ago | parent | prev | next [-] | | I heared the same distinction as OP, but it is the other way around, it's the degree to what a trait is inherited from you parents which cannot be explained by the enviroment or Random Chance. | |
| ▲ | imtringued 4 hours ago | parent | prev | next [-] | | What you're expecting heritability to mean is essentially "are genes responsible for expressing this trait", which is very different from "can I get this trait from my parents?" which does not impose any particular method for passing on the trait. If the study doesn't use sequenced genes of parents and children as input into the model, it can't make the distinction between genetic or non genetic influence by parents. | | |
| ▲ | simiones 3 hours ago | parent [-] | | That is exactly wrong. The measure of heritability used in the scientific literature is very much tied to genetics, just not in a very direct way. That is, heritability is a measure of how much of the variance in a trait is explained by genetics vs environment. In this sense, wealth will have a relatively low heritability, because it is weekly tied to genetics, even though it is very much a trait most people inherit from their parents. Skin color will have a high heritability, because the variance in skin color is almost entirely explained by genetics. The unintuitive part is that traits with almost no genetic variance at all, such as the number of arms, have very low heritability - since, in a population study, almost the entire variance in the number of arms will be explained by environmental factors (very very few families have 1 or 3 arms as a recurring trait - and there are way more people who lose their arms during life). |
| |
| ▲ | hirvi74 17 hours ago | parent | prev | next [-] | | There is a genetic component to alcohol use disorder, for example. But if one is in an environment where there is no access to alcohol whatsoever, then that person, despite their genes, will not develop an alcohol use disorder. The disorder can still be passed from parent to child, but it's more complicated than just genes. | |
| ▲ | kjs3 15 hours ago | parent | prev [-] | | "Welcome to science hell, professor. This is IshKebab, he once saw something on the internet about your field of expertise and is going to spend eternity lecturing you on it."[1] [1] https://www.tomgauld.com/shop/science-hell-print |
|
