I did not base my comment on personal observations. It comes straight from psychology and the big 5.

I was also once an art student myself. Creativity extends far beyond individual contributions, which becomes evident in resource and personnel management. Creativity is highly correlated to openness, as is intelligence, and is least restricted by those who are most eager to exercise decisions and try new things without fear of consequence, whether real or perceived.

Two folk who set the direction of the modern world - Isaac Newton and Charles Darwin.

https://historycollection.com/16-examples-of-the-madness-of-... https://www.science.org/content/article/origin-darwins-anxie...

Can't vouch for the accuracy of these descriptions but they don't suggest lack of neuroticism however brought on. Bodily dysfunction of whatever kind can be causative of course.