Two folk who set the direction of the modern world - Isaac Newton and Charles Darwin.

https://historycollection.com/16-examples-of-the-madness-of-... https://www.science.org/content/article/origin-darwins-anxie...

Can't vouch for the accuracy of these descriptions but they don't suggest lack of neuroticism however brought on. Bodily dysfunction of whatever kind can be causative of course.