Whether or not your VPC can have subnets in multiple regions is entirely unrelated to security.

I meant failure blast radius. Having isolated regions is a core part of the AWS reliability design. AWS has had entire regions fail but these failure have always been isolated to a single region. Global VPCs must rely on globally connected routers that can all fail in ways AWS regional VPCs can't.

	▲	ses1984 3 hours ago \| parent [-]
		If you need global HA to the extent that you're worried about global VPC failure modes, you're going to have to spend a lot of effort to squeeze uptime to the max regardless of where you deploy. Undersea cable failures are probably more likely than a google core networking failure. In AWS a lot of "global" things are actually just hosted in us-east-1.