I meant failure blast radius. Having isolated regions is a core part of the AWS reliability design. AWS has had entire regions fail but these failure have always been isolated to a single region. Global VPCs must rely on globally connected routers that can all fail in ways AWS regional VPCs can't.

If you need global HA to the extent that you're worried about global VPC failure modes, you're going to have to spend a lot of effort to squeeze uptime to the max regardless of where you deploy.

Undersea cable failures are probably more likely than a google core networking failure.

In AWS a lot of "global" things are actually just hosted in us-east-1.