"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship

They already have a human trial in progress...

It is being trialed to prevent muscle weakness and some of those patients will have arthritis and they can be assessed for statistical improvement.

Same thing happened with GLP1

paging Bryan Johnson

Well, the article notes that it seemed effective on human tissue samples.

   The researchers also tested cartilage taken from patients undergoing total knee replacement for osteoarthritis. After one week of treatment with the 15-PGDH inhibitor, the tissue showed fewer 15-PGDH-producing chondrocytes, reduced expression of cartilage degradation and fibrocartilage genes, and early signs of articular cartilage regeneration.

It does get better with physio and exercise. Took me twenty years to recover full (100%) pain-free mobility. It still occasionally finds itself in an uncomfortable spot that can be self-freed, but it can now hold muscle tone across the fascia.

I’m familiar with Helen Blau, her team is into everything: telomeres and aging, reversing cardiomyopathy, HIV, that team is really hardcore into prolonging and improving lives and wellness.

Heard.

But if even one of their interests panned out it would be paradigm changing for millions and they’re doing it to save your lives not get a updoot on hacker news. They’re all pretty anonymous and understated Imo but i am a great fan and i would love for it to be the “year of” anything they’re studying. I listed a few and I’m sure there’s dozens I’m unaware of.

I’ve been thinking that this stuff is all more closely related than we think and that as they go down one of these paths they’re finding all this other stuff along the way, it’s genuinely fascinating.

Heart disease and failure is one of the biggest ways we meet our ends right now. There’s so much interplay between aging processes, ceasing t-cell production, shortening telomeres , that ties in together with this and im glad they see a bigger picture than me having another 20 years , too winded to stand up and piss or strapped to a bed hooked to tubes and groaning!

Survivor bias of those things that haven't been solved.

Notably absent:

The fat pill HIV fix Cystic fibrosis

We make fun of the stuff that hasn't been solved yet ("It's always ten years away!") while ignoring the things that were previously always ten years away until scientists cracked it.

>Year Of The Linux Desktop

After Win11 Microsoft really did all they could to get us there this year.

I feel it's unfair to ding Linux on this, even with the implied "slightly less".

I've had Windows as my main personal computer for practically forever, because of games. Before that it was DOS. That changed a couple months ago.

Literally just now--in preparation for this comment--I decided to try something I never tried before: I mounted my Win10 drive, picked an arbitrary old Windows game EXE (2006 "Prey" game demo), and launched it as a "non-Steam game" with just one little drop-down menu tweak... and it launched! I may get 10 FPS instead of 200, but that's more than I expected off the bat.

In the the "years of the Linux desktop" of my youth, I wasn't nearly as optimistic. In terms of more-recent games, I have little reason to keep my old drive for dual-boot purposes except for specific games that go out of their way to interfere with clumsy anti-cheat rootkits.

I think 'room temperature semiconductors' have been around for a while.

Back on /. (way back when!) I read an article about optic nerve regrowth in mice. IIRC a lattice was built, stem cells shot onto it, and some other stuff was done, and a new optic nerve ended up growing.

It involved removing the poor mouses existing eye, so there was no net gain (still had a mouse with only 1 working eye), but I was hopeful progress would be made so I could get myself a working optic nerve.

Nope. No progress in 20+ years. Someone got a paper published and went on and did something else.

It is a relatively uncommon problem, for ~98% of children with a problem with their optic nerve, patching the opposite eye works to force the optic nerve to grow. I'm in the (un)lucky 2%!

Admittedly not the worst rare health problem to have.

Don't forget about Alzheimer's disease

Battery tech

I guess we should pay scientist to look into the human-to-mice transformation problem

It's all that wheel running, terrible on the knees.

If only a small percentage of studies make it past the mice stage to be tested on humans, it means that a lot more studies have been done on mice than humans. Hence, we know more about mouse biology than human biology. So over time, it must get easier and easier to generate positive results in mice, which are uncorrelated with the success in humans.

Douglas Adams continues to be ahead of his time.

It's because Mickey Mouse has enough money to fund a lot of medical research, and he's not stingy.

We live in the Matrix, and Mice are the overlords.

ra is autoimmune

There's two issues, success rate (about 5%) and time ... even if it is successful in humans, it will be 5 to 10 years before it's available (and 20-30 before it's affordable)

This is not being a contrarian, but a realist.

It has also been tested in cartilage samples from knee replacement surgeries.

Hope you see your dream realized. But know that that stillness is achievable through other activities as well. Most directly and deeply, through a meditation practice which is geared towards reaching those deep meditation states (called Jhanas in the Pali canon). My favorite guide on that particular path is Leigh Brasington.

Can you swim? This is the only thing besides running that gets me there.

I had good results with hyaluronic acid for knee osteoarthritis. Sometimes they sell it as Type II Collagen. "Source Naturals Hyaluronic Joint Complex" was the best for my relatives/friends' knee problems. I take it a few times a month (with resveratrol) for smooth skin. I have been taking it since 2008 without any negative result.

You should check out Michael Levin. Cancerous cells do not grow organ-like structures. Normal cells communicate with other cells as a network to control growth.

No, it's in humans. It's literally the first sentence in your quote.

Ok, we've inmiced the title above. Thanks!