Maybe this is normal for mice but the dose of ketamine used (5-20 mg/kg) seems high? I know mice metabolism is very different but that's in the range of a gram of ketamine for a normal sized human.

The mice may not have been depressed because it's hard to be depressed when you're in a k hole

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cubefox 8 hours ago | parent [-]

I believe drug dosage scales with body surface rather than body mass, which scales differently.

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morkalork 2 hours ago | parent [-]

Depends on the drug, no?

	▲	cubefox an hour ago \| parent [-]
		Not really. There a things like the square-cube law and Kleiber's law which indicate that drugs don't scale with weight. See http://clymer.altervista.org/minor/allometry.html