Here's an example of research that I found to be hard to do in academia with details about why: https://news.ycombinator.com/item?id=31154799

Note that I don't think VCs or DAOs would care about this research either as it's not flashy enough.

I have found that many areas of human knowledge are massively disorganized. Everything is also siloed; knowledge that could easily apply to other domains is hidden by things like specialized terminology.

I think it is because science is systematic, or step-by-step, and not systemic - lacking a "whole system" point of view. Both perspectives are needed to understand a reality made of systems.