| ▲ | OutOfHere 2 days ago |
| The paradoxical B12 deficiency might have a relation with the inactive form being supplemented. If one supplements cyanocobalamin, and one expects the body to convert it to methylcobalamin, and if this conversion doesn't happen for whatever reason, and if the measured form includes the inactive form, then "paradoxical B12 deficiency" can be observed. There is a more insidious form of it whereby the active form doesn't enter the brain. Symptoms are: difficulty speaking, tremors and ataxia. This can be tested by CSF (cerebrospinal fluid) testing. This assumes that the active form is supplemented and it is present in blood. It can be remedied by a course of corticosteroid pills, followed by megadosing B12 orally daily. Refer to PMID 38924428. I take a triple active form of it which is methyl+hydroxy+adenosyl, covering all bases, but a total of just 500 mcg per day, above which it harms my sleep. |
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| ▲ | jdhendrickson 2 days ago | parent | next [-] |
| Would you mind sharing a brand or a link? I have had grey hair since I was in my 20s and struggle with energy. I have been taking nature made multi vitamin for a vitamin b deficiency that was high enough to cause craggy edges on my tongue, caused by the stomach acid suppressant I was prescribed. I would like to compare. |
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| ▲ | notamy 2 days ago | parent | prev | next [-] |
| > The paradoxical B12 deficiency might have a relation with the inactive form being supplemented. Yup, not everyone can convert cyanocobalamin or hydroxocobalamin to adenosyl-/methylcobalamin. Especially in severe cases, anecdotally I’ve seen people not make progress with the standard cyanocobalamin injections, but then make huge progress with methylcobalamin injections. Unfortunately, methylcobalamin is often not preferred in injectable form due to very quick degradation into hydroxocobalamin upon exposure to light. |
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| ▲ | cjsawyer a day ago | parent | next [-] | | Taking methylcobalamin B12 supplements essentially fixed my memory problems. Early on I tried out the cyanocobalamin type and got absolutely nothing from it. If I stop taking the supplements for a few weeks, the memory problems come back. If I start again, a week later my memory is excellent. It’s well worth the minor effort. | |
| ▲ | 2 days ago | parent | prev | next [-] | | [deleted] | |
| ▲ | FollowingTheDao a day ago | parent | prev [-] | | Subligual methylcobalamin works just as well as the shots and you can buy it anywhere. Also, get a Methylmalonic Acid Test with you B12 levels. An MMA test is more useful because it is an enz=yme which uses B12, so when the active form of B12 is low, so will MMA in most cases. | | |
| ▲ | notamy a day ago | parent [-] | | > Subligual methylcobalamin works just as well as the shots It does not. The cobalamin molecules are quite large and don’t penetrate the sublingual mucosa very well. On top of that, the proteins in saliva that bind to B12s will cause any bound B12 to not absorb sublingually, instead having to wait to make it through the digestive system for intestinal uptake. Sublingual is still certainly a better option than oral pills, but the injections are preferable in severe cases for a reason. | | |
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| ▲ | voisin 2 days ago | parent | prev [-] |
| Ok, so assuming you don’t want to have your CSF tested, is there any risk of harm to supplementing with the active form? |
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| ▲ | OutOfHere 2 days ago | parent [-] | | There's no risk in non-smokers if you stick to a sane dose. Megadosing it can harm sleep and severely increase blood pressure and heart rate, although these gradually reverse upon cessation. This can take time to manifest. It is why I limit the dose to 500 mcg per day. Older people, such as those over 70, can need more and tolerate more, even 5 mg per day, due to deteriorated absorption. Also, don't forget the other B vitamins. In truth I take them all. | | |
| ▲ | notamy 2 days ago | parent | next [-] | | > Megadosing it can harm sleep and severely increase blood pressure and heart rate https://www.researchgate.net/profile/Osama-Arafat/publicatio... > METHYLCOBALAMIN HAS AN EFFECT ON HYPOTHALAMIC–HYPOPHYSEAL–
ADRENAL AXIS In rats, but may apply to humans too. | |
| ▲ | Terr_ 2 days ago | parent | prev | next [-] | | > There's no risk in non-smokers if you stick to a sane dose. Also, B12 is water soluble, which generally means that your body is pretty good at flushing out any excess it can't use, making it difficult to overdose on. (Compared to fat-soluble substances.) | | |
| ▲ | OutOfHere a day ago | parent [-] | | A little extra B12 is easily flushed out, but when it's a lot, meaning several milligrams per day for many days, it can quickly and suddenly cause very elevated blood pressure and heart rate, e.g. 160 for both SBP and HR. This effect is easy to undo using a good beta blocker, e.g. atenolol, but if one doesn't, then an emergency hospital visit is required. The point is that despite being water soluble, this adverse effect does happen. Even at just one milligram per day, it can significantly harm sleep. It has a high circulating half life of six days, which implies that it can really build up if repeatedly megadosed in this period. |
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| ▲ | vldmrs 2 days ago | parent | prev [-] | | Does it help you with grey hair ? | | |
| ▲ | OutOfHere a day ago | parent [-] | | No, it's useless to me in this regard, although it could help someone who is efficient. I think my issue may have more to do with copper. |
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