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If I'm reading the study [1] correctly, that conclusion is not warranted.

It appears that they fed the control group and treatment group of mice lots of food to get them fat, then gave them identical normal diets, and gave the treatment group semaglutide.

The semaglutide group lost significantly more weight (fig A.ii) than the control group, and also lost heart muscle.

So it does not seem that they compared to an equivalent amount of weight loss in mice, which is what I'd think you'd need to do to come to the conclusion from the article (actually, not just an equivalent amount of weight loss, but also at the same rate).

[1] https://www.sciencedirect.com/science/article/pii/S2452302X2...

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AuryGlenz 5 days ago | parent [-]

I guess perhaps the better conclusion would be that maybe dosages should be adjusted so that people don’t lose weight too quickly?

	▲	explodingman 3 days ago \| parent [-]
		In its trials, Ozempic was combined with intervention/guidance from nutritionists and fitness advisors, and doctors are supposed to reproduce this by referring patients. You can't do that with mice. I think if I were taking Ozempic I would ask my doctor to halve the rate of progression to higher doses to make the whole process easier to manage, not just managing muscle loss but also the whole of life impact. The official protocol is very "crash diet" in style. Anyone thinking of taking Ozempic should be aware that many people abandon the drug within the first two years, due to too much nausea, diarrhoea and cost.