In its trials, Ozempic was combined with intervention/guidance from nutritionists and fitness advisors, and doctors are supposed to reproduce this by referring patients. You can't do that with mice.

I think if I were taking Ozempic I would ask my doctor to halve the rate of progression to higher doses to make the whole process easier to manage, not just managing muscle loss but also the whole of life impact. The official protocol is very "crash diet" in style.

Anyone thinking of taking Ozempic should be aware that many people abandon the drug within the first two years, due to too much nausea, diarrhoea and cost.