The Apple II had a thing called the monitor, which was a tiny CLI program in ROM that you could invoke from the BASIC command line (CALL -151). With it you got the ability to disassemble memory (300L would spit out 6502 opcodes starting at address 768), set memory regions to sequences of hex digits (300: A9 21 20 FO FD 60 would write a tiny program on an Apple II Plus that printed an exclamation point, if my memory serves), and execute memory (300G).

With these three commands, and a working memory of the hex that corresponded to the opcodes, you could be reasonably productive writing short 6502 programs.

Fun and extremely niche fact: the typo CALL -161 jumped into the monitor, but only after the weird side effect of unhooking the sniffer that watched for DOS 3.3 commands sent via the ROM's text I/O. Not only did this make text print faster -- useful when you were visually dumping memory to the screen to find something quickly, but it also protected against accidentally destroying your disk if you unwittingly printed a sequence like ^M^DINIT HELLO^M, which would trigger the disk initialization routine.