> Virtually all old mice die of cancer, especially in the lab

Bret Weinstein did research on this topic which suggested that this is caused by lab mice having extraordinarily long telomeres which cause them to be good at cell repair but bad at limiting neoplasm growth due to delayed apoptosis. The result of this combination would be that lab tests on potential damage done by preparations on these mice is less valid 'cause they are better at repairing such damage than the average mammal due to those long telomeres. It also means nearly all these mice succumb to cancer. They're not normal mice, at all.

The reserve-capacity hypothesis: evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair

Bret S Weinstein 1 , Deborah Ciszek

https://pubmed.ncbi.nlm.nih.gov/11909679/

This paper examined captive wild mice, which they caught themselves on school grounds, and noted that "mice in both feeding groups died from various causes, chief among these a range of cancers":

> https://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2006...

So I think that even wild mice are prone to immune aging and cancer development.