Something similar to abliteration would work, after all abliteration removes the alignment virus, why not the others? Fine-tuning can be used too, there are many options as long as the weights are available.

On the other hand, nothing can be done to fix closed models, nobody knows how they work, how they select the targets for their attacks or the nature of those attacks - even conventional alignment can introduce dangerous cognitive viruses.

The only way to be sure is to have open weights models with fully open abliteration and fine-tuning - both the process and data.