I'm using three monitors with 2 DPI (4K/42" x2 and one 1920x1200 turned portrait) with XFCE.

When I first connected it, I set a multiplier for the portrait monitor and I haven't thought about it since. It holds a chat system, status bar, notifications and background music.

Yeah, I'm using a fairly esoteric dual-screen laptop in Xfce which took five minutes of xrandr to get it's 2x mode looking great. Keep expecting to be forced to use Wayland one day, but it's not happened yet.