This is much more of a problem if you're attempting to run at a massive scale, beyond what humans can audit. When I'm doing "artisanal" agentic programming, I'm still in the loop in the sense that I'm watching what it's doing and ready to hit Esc if it is doing something dumb. If the AI trips over the sandbox, I can cancel it and do whatever it wants me to do before it starts trying to engineer its way around.