I'm curious if you've tried any methods to increase your endogenous GLP-1 activity?

These include things like loading your body earlier in the day with heavy protein and fermented foods, eating proteins and vegetables before carbs (make less room for carbs), and of course there is still the lower stress, improve sleep and exercise.

I'm not suggesting these are replacements, but potentially like a micro-dose response.

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zemoerfi 3 days ago | parent | next [-]

Natural GLP 1 is an extremely different molecule to these drugs. Natural GLP 1 gets used in minutes. It's like a house key. It fits in the lock, and it's easy to remove.

These GLP 1 drugs are huge molecules with a GLP 1 shaped key on them. It's like a house key attached to a school bus. Once it's in your lock, that key is going to be a pain to remove.

Stimulating natural GLP 1 helps for a few minutes. Using these drugs can help for a week.

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Sohcahtoa82 3 days ago | parent | prev [-]

I'm not the GP, but I can answer this.

I did try keto before. Heavy protein, low carbs. Everyone promised a high protein/fat/fiber diet with low starch/sugar was the secret to feeling full sooner and for longer.

Nope. Didn't change a damn thing. I was still hungry all the time.

My experience mirrors the GP. Ozempic really flipped the switch. See my other comment (https://news.ycombinator.com/item?id=50399564) for more.

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gib444 3 days ago | parent | next [-]

GP here, yup, was about to write something like that.

I don't really like fermented foods and I avoid dairy. Only have heavy carbs a few times a month. Mostly it's meat, vegetables, fruit. I've done various diets as a result of trying to fix other issues but none move the needle on the food noise

I've also had no stress for like, a year now due to my circumstances

	▲	i2amsam 2 days ago \| parent [-]
		I’ll add, I did keto and found I lost weight and was relatively able to control hunger, but my food choices were very narrow and everything needed careful planning, additionally my cholesterol and blood lipids went up a concerning amount, enough that my doctor recommended medication. On a glp I don’t need to carefully plan my diet because carb-heavy or greasy foods are unappealing to consider. It’s a very strange feeling for me to look at a big menu and realize I want to order the salad, not that I “should”, and my cholesterol levels fell by 66%

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GeoAtreides 2 days ago | parent | prev [-]

I'm going to say something brave and controversial (/s), and I'll accept the downvotes and flagging: I don't believe you. I don't believe keto (or keto-ish) didn't lead to lower hunger cravings. Maybe you're missing some things from your story? maybe you're misremembering some things?