I did some experiments translating a typed subset of Python to C for small system use, certain features like lists of primitive types, generators and comprehensions, frozendict, simple classes, generic functions, etc, map with little or no cost but are so much cleaner than the equivalent code in plain C. You also get to write test harnesses using all the tools available to full Python. The main issue is unsurprisingly memory management, Obj-C / Swift style automatic reference counting works but has drawbacks, and it gets much more complicated if you want to mix the static and CPython code.

The static + AOT approach has a lot of promise now that type annotations are widely adopted, predictable behavior and good performance on code that is mostly idiomatic Python seem like a good alternative in many situations to the weight of Rust.