From the physics, not without more breakthroughs, and even then I can't imagine what that would look like. The particle physics that you can use industrially has long been understood, and the field has long been long stuck because the only things we don't understand are also insanely expensive to experimentally access. Maybe once we move up the Kardashev scale, though.

ETH sounds more like there's a path it could become important? In general, the recent complexity results suggest that a) our intuitions about that world are unreliable, and b) the truth seems to be insanely complicated. I mean, new faster multiplication algorithms in 2026, what the hell? How can we say anything about the full space of all possible algorithms?

If we had really good understanding of physics, couldn't we find out how to make a room temperature superconductor (or prove it can't exist)?

Or is such understanding reliant in experimentation because there are "hidden constants" we can't figure out with math alone?