It takes 2 seconds for a human to remove an ad from media. It happens so fast there are even browser plugins (sponsorblock) which crowdsource removing sponsorship plugs from youtube videos.

You can do it with ffmpeg losslessly with pretty much any media.

The only thing that's hard to remove is sponsorships built into the script (brought to you by snapple), but people don't tend to like that sort of thing in a show.