Even compared with C, assembly gives you minimal guardrails, which makes it harder to write correct programs at scale. An e-commerce web app is going to be a large program that's online and an attractive target for attackers. You will need more discipline, experience, and tooling to prevent bugs, including bugs only made possible by your choice of language. (For example, assembly opens up a category of control flow bugs that are prevented by structured control flow. Data corruption is easier because you don't work with named, scoped variables.)

If isn't a question of "could" but how likely you are to get good outcomes.