I'm reminded of the joke that the most dangerous thing in the ocean is all the water.

We don't have fuel sources that can run long enough for the trip, and deep space won't have enough solar radiation. We would need reliable mining spots along the way to replace metals made brittle by exposure or punctured by micro asteroids.

Even travelling at 1% the speed of light, stray hydrogen atoms become a problem. Not counting acceleration or deceleration time, that would be over 400 years just to get to the nearest star, let alone one with a habitable planet.

In all current realistic plans the idea is to accelerate once and decelerate (if needed) at the destination. So not really doable to stop by on the way, unless you are going really slow - or its a part of the Voyage (e.g. multi millennia round trip where you replenish in every suitable star system along the way) provided your ship can handle the acceleration (could be assisted by built infra) and deceleration of a given "hop".