If this worries you, can try the cultivar Wells, selected by its low level of acetogenins.

Wild paw paws with high levels of acetogenins announce it, with horrible flavor. The domestic fruits are selected against. A correct amount adds a lot of complexity to the flavor, so can be desirable in a fruit that you eat just a month at year. I bet that you never worry about the fact that your potatoes have a little bit of solanin after all.

> I bet that you never worry about the fact that your potatoes have a little bit of solanin after all

In fairness, solanine is purely an acute poison, while annonacin has cumulative effects. Not that the compound itself bioaccumulates but the damage it causes does.

If you already have any parkinsons symptoms whatsoever, pawpaw amounts greater than 0.2 fruits per year have been shown to worsen them.